American Heart Journal
Volume 154, Issue 3 , Pages 554-560 , September 2007

Intensity of lipid-lowering therapy and low-density lipoprotein cholesterol goal attainment among the elderly before and after the 2004 National Cholesterol Education Program Adult Treatment Panel III update

  • Gregory A. Nichols, PhD

      Affiliations

    • Kaiser Permanente Center for Health Research, Portland, OR
    • Corresponding Author InformationReprint requests: Gregory A. Nichols, PhD, Center for Health Research, 3800 N Interstate Avenue, Portland, OR 97227-1098.
    • ,
  • Soma Nag, PhD

      Affiliations

    • Merck & Co, Inc, West Point, PA
    • ,
  • Wiley Chan, MD

      Affiliations

    • Northwest Permanente, PC, Portland, OR

Received 1 February 2007 ,Accepted 14 April 2007.

References 

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  2. Shepherd J, Blauw GJ, Murphy MB, et al. Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial. PROspective Study of Pravastatin in the Elderly at Risk. Lancet. 2002;360:1623–1630
  3. ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial.. Major outcomes in moderately hypercholesterolemic, hypertensive patients randomized to pravastatin vs usual care: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT-LLT). JAMA. 2002;288:2998–3007
  4. Sever PS, Poulter NR, Dahlof B, et al. Reduction in cardiovascular events with atorvastatin in 2,532 patients with type 2 diabetes: Anglo-Scandinavian Cardiac Outcomes Trial–lipid-lowering arm (ASCOT-LLA). Diabetes Care. 2005;28:1151–1157
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  7. Pearson TA, Laurora I, Chu H, et al. The lipid treatment assessment project (L-TAP): a multicenter survey to evaluate the percentages of dyslipidemic patients receiving lipid-lowering therapy and achieving low-density lipoprotein cholesterol goals. Arch Intern Med. 2000;160:459–467
  8. Yan AT, Yan RT, Tan M, et al. Contemporary management of dyslipidemia in high-risk patients: targets still not met. Am J Med. 2006;119:676–683
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  12. Shepherd J, Barter P, Carmena R, et al. Effect of lowering LDL cholesterol substantially below currently recommended levels in patients with coronary heart disease and diabetes: The Treating to New Targets (TNT) Study. Diabetes Care. 2006;29:1220–1226
  13. Hayward RA, Hofer TP, Vijan S. Narrative review: lack of evidence for recommended low-density lipoprotein treatment targets: a solvable problem. Ann Intern Med. 2006;145:520–530
  14. Nissen SE, Tuzcu EM, Schoenhagen P, et al. Effect of intensive compared with moderate lipid-lowering therapy on progression of coronary atherosclerosis: a randomized controlled trial. JAMA. 2004;291:1071–1080
  15. Massing MW, Sueta CA, Chowdhury M, et al. Lipid management among coronary artery disease patients with diabetes mellitus or advanced age. Am J Cardiol. 2001;87:646–649
  16. Afonso NW, Nassif G, Aranha ANF, et al. Low-density lipoprotein cholesterol goal attainment among high risk patients: does a combined intervention targeting patients and providers work?. Am J Manag Care. 2006;12:589–594

 Merck & Co, Inc, provided funding for this research.

PII: S0002-8703(07)00361-4

doi: 10.1016/j.ahj.2007.04.037

American Heart Journal
Volume 154, Issue 3 , Pages 554-560 , September 2007

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