American Heart Journal
Volume 154, Issue 2 , Pages 267-277, August 2007

The safety of intravenous diuretics alone versus diuretics plus parenteral vasoactive therapies in hospitalized patients with acutely decompensated heart failure: A propensity score and instrumental variable analysis using the Acutely Decompensated Heart Failure National Registry (ADHERE) database

  • Maria Rosa Costanzo, MD, FACC

      Affiliations

    • Midwest Heart Foundation, Lombard, IL
    • Corresponding Author InformationReprint requests: Maria Rosa Costanzo, MD, FACC, Edward Hospital Center for Advanced Heart Failure, Midwest Heart Specialists, 801 South Washington Street, PO Box 3226, Naperville, IL 60566.
    • ,
  • R.S. Johannes, MD, MS

      Affiliations

    • Cardinal Health Clinical Research Group, Marlborough, MA
    • Brigham and Women's Hospital, Harvard Medical School, Boston, MA
    • ,
  • Michael Pine, MD, MBA, FACC

      Affiliations

    • Michael Pine and Associates, Inc, Chicago, IL
    • The University of Chicago, Chicago, IL
    • ,
  • Vikas Gupta, PharmD, BCPS

      Affiliations

    • Cardinal Health Clinical Research Group, Marlborough, MA
    • ,
  • Mitchell Saltzberg, MD, FACC

      Affiliations

    • Midwest Heart Foundation, Lombard, IL
    • ,
  • Joel Hay, PhD

      Affiliations

    • Pharmaceutical Economics and Policy, University of Southern California School of Pharmacy, Los Angeles, CA
    • ,
  • Clyde W. Yancy, MD, FACC

      Affiliations

    • Baylor Heart and Vascular Institute, Dallas, TX
    • ,
  • Gregg C. Fonarow, MD, FACC

      Affiliations

    • Ahmanson-UCLA Cardiomyopathy Center, University of California, Los Angeles, Los Angeles, CA

Received 30 October 2006; accepted 16 April 2007. published online 04 June 2007.

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 Dr Costanzo, Dr Saltzberg, Dr Yancy, and Dr Fonarow have received honoraria and have served as consultants for Scios Inc. Dr Gupta has received honoraria from Scios Inc, Mountain View, CA. Dr Hay has served as a consultant to Scios Inc. The Acutely Decompensated Heart Failure National Registry (ADHERE) and this study were funded by Scios Inc. Access to the ADHERE database was provided by the Scientific Advisory Committee for ADHERE. The investigators designed and executed the analysis and prepared this manuscript independent of the sponsor, Scios Inc. The sponsor reviewed the results of the analysis and the manuscript. However, neither results nor manuscript were altered as a consequence of the sponsor's review.

 Dr Costanzo had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. The study concept and design were by Costanzo, Johannes, Pine, Gupta, Hay, Fonarow, and Yancy. Acquisition of data was done by Johannes, Pine, and Gupta; analysis and interpretation of data by Costanzo, Johannes, Pine, Gupta, Saltzberg, Hay, Yancy, and Fonarow; drafting of the manuscript by Costanzo, Johannes, Pine, and Gupta; critical revision of the manuscript for important intellectual content by Costanzo, Johannes, Pine, Gupta, Saltzberg, Hay, Yancy, and Fonarow. Statistical expertise was provided by Johannes, Pine, and Hay; funding obtained by Johannes and Gupta; and administrative, technical, or material support obtained by Johannes, Pine, Gupta, and Hay. Study supervision was done by Johannes, Pine, and Gupta.

PII: S0002-8703(07)00357-2

doi:10.1016/j.ahj.2007.04.033

American Heart Journal
Volume 154, Issue 2 , Pages 267-277, August 2007

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