American Heart Journal
Volume 154, Issue 2 , Pages 278-284 , August 2007

Coexistence and exercise exacerbation of intraleft ventricular contractile dyssynchrony in hypertensive patients with diastolic heart failure

  • Yi-Chih Wang, MD

      Affiliations

    • Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    • ,
  • Juey-Jen Hwang, MD

      Affiliations

    • Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    • ,
  • Ling-Ping Lai, MD

      Affiliations

    • Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    • ,
  • Chia-Ti Tsai, MD

      Affiliations

    • Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    • ,
  • Lung-Chun Lin, MD

      Affiliations

    • Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    • ,
  • Rodolphe Katra, Ph

      Affiliations

    • New Therapies & Diagnostic Research, Cardiac Disease Management, Medtronic, Inc., Minneapolis, MN
    • ,
  • Jiunn-Lee Lin, MD

      Affiliations

    • Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    • Corresponding Author InformationReprint requests: Jiunn-Lee Lin, MD, No. 7, Chung-San South Rd, National Taiwan University Hospital, Taipei 100, Taiwan.

Received 8 October 2006 ,Accepted 2 April 2007.

References 

  1. Redfield MM, Jacobsen SJ, Burnett JC, et al. Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic. JAMA. 2003;289:194–202
  2. Zile MR, Brutsaert DL. New concepts in diastolic dysfunction and diastolic heart failure. I. Diagnosis, prognosis, measurements of diastolic function. Circulation. 2002;105:1387–1393
  3. Poulsen SH, Anderson NH, Ivarsen PI, et al. Doppler tissue imaging reveals systolic dysfunction in patients with hypertension and apparent “isolated” diastolic dysfunction. J Am Soc Echocardiogr. 2003;16:724–731
  4. Aurigemma GP, Silver KH, Priest MA, et al. Geometric changes allow normal ejection fraction despite depressed myocardial shortening in hypertensive left ventricular hypertrophy. J Am Coll Cardiol. 1995;26:195–202
  5. Zile MR, Brutsaert DL. New concepts in diastolic dysfunction and diastolic heart failure: part II: causal mechanisms and treatment. Circulation. 2002;105:1503–1508
  6. Penicka M, Bartunek J, De Bruyne B, et al. Improvement of left ventricular function after cardiac resynchronization therapy is predicted by tissue Doppler imaging echocardiography. Circulation. 2004;109:978–983
  7. Leclercq C, Faris O, Tunin R, et al. Systolic improvement and mechanical resynchronization does not require electrical synchrony in the dilated failing heart with left bundle-branch block. Circulation. 2002;106:1760–1763
  8. Bader H, Garrigue S, Lafitte S, et al. Intra-left ventricular electromechanical asynchrony: a new independent predictor of severe cardiac events in heart failure patients. J Am Coll Cardiol. 2004;43:248–256
  9. Chobanian AV, Bakris GL, Black HR, et al. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. JAMA. 2003;289:2560–2571
  10. Kitzman D, Sheikh KH, Beere PA, et al. Age related alterations of Doppler left ventricular filling in normal subjects are independent of left ventricular mass, heart rate, contractility and loading conditions. J Am Coll Cardiol. 1991;18:1243–1250
  11. Sohn DW, Chai IH, Lee DJ, et al. Assessment of mitral annulus velocity by Doppler tissue imaging in the evaluation of left ventricular diastolic function. J Am Coll Cardiol. 1997;30:474–480
  12. Mottram PM, Haluska B, Leano R, et al. Effect of aldosterone antagonism on myocardial dysfunction in hypertensive patients with diastolic heart failure. Circulation. 2004;110:558–565
  13. Yu CM, Lin H, Zhang Q, et al. High prevalence of left ventricular systolic and diastolic asynchrony in patients with congestive heart failure and normal QRS duration. Heart. 2003;89:54–60
  14. Baicu CF, Zile MR, Aurigemma GP, et al. Left ventricular systolic performance, function, and contractility in patients with diastolic heart failure. Circulation. 2005;111:2306–2312
  15. Yu CM, Lin H, Yang H, et al. Progression of systolic abnormalities in patients with “isolated” diastolic heart failure and diastolic dysfunction. Circulation. 2002;105:1195–1201
  16. Petrie MC, Caruana L, Berry C, et al. “Diastolic heart failure” or heart failure caused by subtle left ventricular systolic dysfunction?. Heart. 2002;87:29–31
  17. Yu CM, Yang H, Lau CP, et al. Regional left ventricle mechanical asynchrony in patients with heart disease and normal QRS duration: implication for biventricular pacing therapy. Pacing Clin Electrophysiol. 2003;2p1:562–570
  18. De Sutter J, Van de Veire NR, Muyldermans L, et al. Prevalence of mechanical dyssynchrony in patients with heart failure and preserved left ventricular function (a report from the Belgian multicenter registry on dyssynchrony). Am J Cardiol. 2005;96:1543–1548
  19. Mottram PM, Haluska BA, Marwick TH. Response of B-type natriuretic peptide to exercise in hypertensive patients with suspected diastolic heart failure: correlation with cardiac function, hemodynamics, and workload. Am Heart J. 2004;148:365–370
  20. Kanzaki H, Bazaz R, Schwartzman D, et al. A mechanism for immediate reduction in mitral regurgitation after cardiac resynchronization therapy: insights from mechanical activation strain mapping. J Am Coll Cardiol. 2004;44:1619–1625
  21. Knaapen P, van Campen L, de Cock C, et al. Effects of cardiac resynchronization therapy on myocardial perfusion reserve. Circulation. 2004;110:646–651
  22. McDonagh TA, Robb SD, Murdoch DR, et al. Biochemical detection of left ventricular systolic dysfunction. Lancet. 1998;62:60A–66A
  23. Dahlström U. Can natriuretic peptides be used for the diagnosis of diastolic heart failure?. Eur J Heart Fail. 2004;6:281–287
  24. Breithardt OA, Stellbrink C, Kramer AP, et al. PATH-CHF Study Group Echocardiographic quantification of left ventricular asynchrony predicts an acute hemodynamic benefit of cardiac resynchronization therapy. J Am Coll Cardiol. 2002;40:536–545
  25. Abraham WT, Fisher WG, Smith AL, et al. for the MIRACLE Study Group Cardiac resynchronization in chronic heart failure: Multicenter InSync Randomized Clinical Evaluation (MIRACLE). N Engl J Med. 2002;346:1845–1853

PII: S0002-8703(07)00286-4

doi: 10.1016/j.ahj.2007.04.008

American Heart Journal
Volume 154, Issue 2 , Pages 278-284 , August 2007

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