American Heart Journal
Volume 152, Issue 3 , Pages 434-441 , September 2006

Intracoronary infusion of autologous mononuclear bone marrow cells or peripheral mononuclear blood cells after primary percutaneous coronary intervention: Rationale and design of the HEBE trial—A prospective, multicenter, randomized trial

  • Alexander Hirsch, MD

      Affiliations

    • Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    • First 3 authors contributed equally to the manuscript, and their names are provided in alphabetical order.
    • ,
  • Robin Nijveldt, MD

      Affiliations

    • Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
    • First 3 authors contributed equally to the manuscript, and their names are provided in alphabetical order.
    • ,
  • Pieter A. van der Vleuten, MD

      Affiliations

    • Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    • First 3 authors contributed equally to the manuscript, and their names are provided in alphabetical order.
    • ,
  • Bart J. Biemond, MD, PhD

      Affiliations

    • Department of Haematology, Academic Medical Center, Amsterdam, The Netherlands
    • ,
  • Pieter A. Doevendans, MD, PhD

      Affiliations

    • Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands
    • ,
  • Albert C. van Rossum, MD, PhD

      Affiliations

    • Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
    • ,
  • Jan G. Tijssen, PhD

      Affiliations

    • Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    • ,
  • Felix Zijlstra, MD, PhD

      Affiliations

    • Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    • ,
  • Jan J. Piek, MD, PhD

      Affiliations

    • Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    • Corresponding Author InformationReprints requests: Jan J. Piek, MD, PhD, FESC, FACC, Department of Cardiology, Academic Medical Center, PO Box 22660, 1100 DD, Amsterdam, The Netherlands.
    • ,
  • on behalf of the HEBE investigators

Received 13 October 2005 ,Accepted 7 February 2006.

References 

  1. Orlic D, Kajstura J, Chimenti S, et al. Bone marrow cells regenerate infarcted myocardium. Nature. 2001;410:701–705
  2. Kocher AA, Schuster MD, Szabolcs MJ, et al. Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat Med. 2001;7:430–436
  3. Orlic D, Kajstura J, Chimenti S, et al. Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc Natl Acad Sci U S A. 2001;98:10344–10349
  4. Tomita S, Mickle DA, Weisel RD, et al. Improved heart function with myogenesis and angiogenesis after autologous porcine bone marrow stromal cell transplantation. J Thorac Cardiovasc Surg. 2002;123:1132–1140
  5. Kajstura J, Rota M, Whang B, et al. Bone marrow cells differentiate in cardiac cell lineages after infarction independently of cell fusion. Circ Res. 2005;96:127–137
  6. Balsam LB, Wagers AJ, Christensen JL, et al. Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium. Nature. 2004;428:668–673
  7. Bel A, Messas E, Agbulut O, et al. Transplantation of autologous fresh bone marrow into infarcted myocardium: a word of caution. Circulation. 2003;108(Suppl 1):II247–II252
  8. Murry CE, Soonpaa MH, Reinecke H, et al. Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature. 2004;428:664–668
  9. Wollert KC, Drexler H. Clinical applications of stem cells for the heart. Circ Res. 2005;96:151–163
  10. Strauer BE, Brehm M, Zeus T, et al. Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans. Circulation. 2002;106:1913–1918
  11. Schachinger V, Assmus B, Britten MB, et al. Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction: final one-year results of the TOPCARE-AMI trial. J Am Coll Cardiol. 2004;44:1690–1699
  12. Britten MB, Abolmaali ND, Assmus B, et al. Infarct remodeling after intracoronary progenitor cell treatment in patients with acute myocardial infarction (TOPCARE-AMI): mechanistic insights from serial contrast-enhanced magnetic resonance imaging. Circulation. 2003;108:2212–2218
  13. Assmus B, Schachinger V, Teupe C, et al. Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI). Circulation. 2002;106:3009–3017
  14. Wollert KC, Meyer GP, Lotz J, et al. Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial. Lancet. 2004;364:141–148
  15. Yoshioka T, Ageyama N, Shibata H, et al. Repair of infarcted myocardium mediated by transplanted bone marrow–derived CD34+ stem cells in a nonhuman primate model. Stem Cells. 2005;23:355–364
  16. Fernandez-Aviles F, San J, Roman A, et al. Experimental and clinical regenerative capability of human bone marrow cells after myocardial infarction. Circ Res. 2004;95:742–748
  17. Janssens S, Dubois C, Bogaert J, et al. Autologous bone marrow-derived stem-cell transfer in patients with ST-segment elevation myocardial infarction: double-blind, randomized controlled trial. Lancet. 2006;367:113–121
  18. Bartunek J, Vanderheyden M, Vandekerckhove B, et al. Intracoronary injection of CD133-positive enriched bone marrow progenitor cells promotes cardiac recovery after recent myocardial infarction—feasibility and safety. Circulation. 2005;112:I178–I183

 Robin Nijveldt, MD was supported by a grant from The Netherlands Heart Foundation (2003B126).

 The study is financially supported by funds provided by the ICIN, the Dutch Heart Foundation, and by unrestricted grants from Biotronik, Boston Scientific, Guerbet, Guidant, Medtronic, Novartis, Pfizer, and Sanofi-Aventis.

PII: S0002-8703(06)00133-5

doi: 10.1016/j.ahj.2006.02.007

American Heart Journal
Volume 152, Issue 3 , Pages 434-441 , September 2006

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