American Heart Journal
Volume 152, Issue 3 , Pages 427-433 , September 2006

Design of a large cross-sectional study to facilitate future clinical trials in children with the Fontan palliation

  • Lynn A. Sleeper, ScD

      Affiliations

    • New England Research Institutes, Watertown, MA
    • Corresponding Author InformationReprint requests: Lynn A. Sleeper, ScD, New England Research Institutes, 9 Galen Street, Watertown, MA 02472.
    • ,
  • Page Anderson, MD

      Affiliations

    • Duke University Medical Center, Durham, NC
    • ,
  • Daphne T. Hsu, MD

      Affiliations

    • Columbia University Medical Center, New York, NY
    • ,
  • Lynn Mahony, MD

      Affiliations

    • University of Texas Southwestern Medical Center, Dallas, TX
    • ,
  • Brian W. McCrindle, MD, MPH

      Affiliations

    • The Hospital for Sick Children, Toronto, Ontario, Canada
    • ,
  • Stephen J. Roth, MD, MPH

      Affiliations

    • Children's Hospital Boston, Boston, MA
    • ,
  • J. Phillip Saul, MD

      Affiliations

    • Medical University of South Carolina, Charleston, SC
    • ,
  • Richard V. Williams, MD

      Affiliations

    • Primary Children's Medical Center, Salt Lake City, UT
    • ,
  • Tal Geva, MD

      Affiliations

    • Children's Hospital Boston, Boston, MA
    • ,
  • Steven D. Colan, MD

      Affiliations

    • Children's Hospital Boston, Boston, MA
    • ,
  • Bernard J. Clark, MD

      Affiliations

    • Children's Hospital of Philadelphia, Philadelphia, PA
    • ,
  • for the Pediatric Heart Network Investigators

Received 18 July 2005 ,Accepted 7 February 2006.

References 

  1. Marino BS. Outcomes after the Fontan procedure. Curr Opin Pediatr. 2002;14:620–626
  2. van den Bosch AE, Roos-Hesselink JW, Van Domburg R, et al. Long-term outcome and quality of life in adult patients after the Fontan operation. Am J Cardiol. 2004;93:1141–1145
  3. Penny DJ, Rigby ML, Redington A. Abnormal patterns of intraventricular flow and diastolic filling after the Fontan operation: evidence of incoordinate ventricular wall motion. Br Heart J. 1991;66:375–378
  4. Fogel M, Weinber P, Chin A, et al. Late ventricular geometry and performance changes of functional single ventricle throughout staged Fontan reconstruction assessed by magnetic resonance imaging. J Am Coll Cardiol. 1996;28:212–221
  5. Fogel MA. Assessment of cardiac function by MRI. Pediatr Cardiol. 2000;21:59–69
  6. Eicken A, Fratz S, Gutfried C, et al. Hearts late after Fontan operation have normal mass, normal volume, and reduced systolic function: a magnetic resonance imaging study. J Am Coll Cardiol. 2003;42:1061–1065
  7. Gamba A, Merlo M, Fiocchi R, et al. Heart transplantation in patients with previous Fontan operations. J Thorac Cardiovasc Surg. 2004;127:555–556
  8. Michielon G, Parisi F, Di Carlo D, et al. Orthotopic heart transplantation for failing single ventricle physiology. Eur J Cardiothorac Surg. 2003;24:502–510
  9. Driscoll D, Danielson G, Puga F, et al. Exercise tolerance and cardiorespiratory response to exercise after the Fontan operation for tricuspid atresia or functional single ventricle. J Am Coll Cardiol. 1986;7:1087–1094
  10. Gewillig M, Lundstrom U, Bull C, et al. Exercise responses in patients with congenital heart disease after Fontan repair: patterns and determinants of performance. J Am Coll Cardiol. 1990;15:1424–1432
  11. Reybrouck T, Rogers R, Weymans M, et al. Serial cardiorespiratory exercise testing in patients with congenital heart disease. Eur J Pediatr. 1995;154:801–806
  12. Feldt R, Driscoll D, Offord K, et al. Protein-losing enteropathy after the Fontan operation. J Thorac Cardiovasc Surg. 1996;112:672–680
  13. Mertens L, Hagler DJ, Sauer U, et al. Protein-losing enteropathy after the Fontan operation: an international multicenter study. PLE Study Group. J Thorac Cardiovasc Surg. 1998;115:1063–1073
  14. Kaulitz R, Ziemer G, Bergmann F, et al. Atrial thrombus after the Fontan operation: predisposing factors, treatment and prophylaxis. Cardiol Young. 1997;7:37–43
  15. Monagle P, Karl TR. Thromboembolic problems after the Fontan operation. Semin Thorac Cardiovasc Surg Pediatr Card Surg Ann. 2002;5:36–47
  16. Weipert J, Noebauer C, Schreiber C, et al. Occurrence and management of atrial arrhythmia after long-term Fontan circulation. J Thorac Cardiovasc Surg. 2004;127:457–464
  17. Landgraf JM, Abetz L, Ware JE. The CHQ User's Manual. Boston (Mass): Health Act; 1999;[Second Printing]
  18. Kendall L, Lewin RJ, Parsons JM, et al. Factors associated with self-perceived state of health in adolescents with congenital cardiac disease attending paediatric cardiologic clinics. Cardiol Young. 2001;11:431–438
  19. Zile MR, Brutsaert DL. New concepts in diastolic dysfunction and diastolic heart failure: Part I: diagnosis, prognosis, and measurements of diastolic function. Circulation. 2002;105:1387–1393
  20. Milanesi O, Stellin G, Colan SD, et al. Systolic and diastolic performance late after the Fontan procedure for a single ventricle and comparison of those undergoing operation at <12 months of age and at >12 months of age. Am J Cardiol. 2002;276–280
  21. Germain P, Roul G, Kastler B, et al. Inter-study variability in left ventricular mass measurement. Comparison between M-mode echography and MRI. Eur Heart J. 1992;13:1011–1019
  22. Bellenger NG, Davies LC, Frances JM, et al. Reduction in sample size for studies of remodeling in heart failure by the use of cardiovascular magnetic resonance. J Cardiovasc Magn Reson. 2000;2:271–278
  23. Yoshimura M, Yasue H, Okumura K, et al. Different secretion patterns of atrial and natriuretic peptide and brain natriuretic peptide in patients with congestive heart failure. Circulation. 1993;87:464–469
  24. Dao Q, Krishnaswamy P, Kazanegra R, et al. Utility of brain natiuretic peptide in the diagnosis of congestive heart failure in an urgent-care setting. J Am Coll Cardiol. 2001;37:379–385
  25. Morrison LK, Harrison A, Krishnaswamy P, et al. Utility of a rapid B-natriuretic peptide assay in differentiating congestive heart failure from lung disease in patients presenting with dyspnea. J Am Coll Cardiol. 2002;39:202–209
  26. Lemos J, Morrow D, Bentley J, et al. The prognostic value of brain natriuretic peptide in patients with acute coronary syndromes. N Engl J Med. 2001;345:1014–1021
  27. Tsutamoto T, Wada A, Maeda K, et al. Attenuation of compensation of endogenous cardiac natriuretic peptide system in chronic heart failure: prognostic role of plasma brain natriuretic peptide concentration in patients with chronic symptomatic left ventricular dysfunction. Circulation. 1997;96:509–516
  28. Ationu A, Singer D, Smiath A, et al. Studies of cardiopulmonary bypass in children: implications for the regulation of brain natriuretic peptic. Cardiovasc Res. 1993;27:1538–1541
  29. Yoshimura N, Yamaguchi M, Oshima Y, et al. Suppression of the secretion of atrial and brain natriuretic peptide after total cavopulmonary connection. J Thorac Cardiovasc Surg. 2000;120:764–769
  30. Hjortdal V, Stenbog E, Ravn H, et al. Neurohormonal activation late after cavopulmonary connection. Heart. 2000;83:439–443
  31. Steinberger EK, Ferencz C, Loffredo CA. Infants with single ventricle: a population-based epidemiological study. Teratology. 2002;65:106–115
  32. Fyler DC, Buckley LP, Hellenbrand W. Report of the New England regional infant cardiac program. Pediatrics. 1980;65:376–461

 This work was supported by grants from the National Heart, Lung and Blood Institute, NIH/DHHS, Bethesda, MD, #U01 HL68270 (Sleeper, Geva, Colan), U01 HL068269 (Anderson), U01 HL068292 (Williams), U01 HL068290 (Hsu), U01 HL068288 (McCrindle), U01 HL068285 (Roth), U01 HL068281 (Saul), and U01 HL068279 (Clark).

PII: S0002-8703(06)00132-3

doi: 10.1016/j.ahj.2006.02.009

American Heart Journal
Volume 152, Issue 3 , Pages 427-433 , September 2006

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