American Heart Journal
Volume 151, Issue 4 , Pages 922.e1-922.e5 , April 2006

Transcatheter patent foramen ovale closure mitigates aura migraine headaches abolishing spontaneous right-to-left shunting

  • Alessandro Giardini, MD

      Affiliations

    • Pediatric Cardiology and Adult Congenital Unit, University of Bologna, Italy
    • Corresponding Author InformationReprint requests: Alessandro Giardini, MD, Pediatric Cardiology and Adult Congenital Unit, University of Bologna, Via Massarenti 9, 40138, Bologna, Italy.
    • ,
  • Andrea Donti, MD

      Affiliations

    • Pediatric Cardiology and Adult Congenital Unit, University of Bologna, Italy
    • ,
  • Roberto Formigari, MD

      Affiliations

    • Pediatric Cardiology and Adult Congenital Unit, University of Bologna, Italy
    • ,
  • Luisa Salomone, MD

      Affiliations

    • Pediatric Cardiology and Adult Congenital Unit, University of Bologna, Italy
    • ,
  • Daniela Prandstraller, MD

      Affiliations

    • Pediatric Cardiology and Adult Congenital Unit, University of Bologna, Italy
    • ,
  • Marco Bonvicini, MD

      Affiliations

    • Pediatric Cardiology and Adult Congenital Unit, University of Bologna, Italy
    • ,
  • Gualtiero Palareti, MD

      Affiliations

    • Department of Angiology, University of Bologna, Italy
    • ,
  • Donata Guidetti, MD

      Affiliations

    • Department of Neurology, Santa Maria Nuova Hospital, Reggio Emilia, Italy
    • ,
  • Oscar Gaddi, MD

      Affiliations

    • Department of Cardiology, Santa Maria Nuova Hospital, Reggio Emilia, Italy
    • ,
  • Fernando Maria Picchio, MD

      Affiliations

    • Pediatric Cardiology and Adult Congenital Unit, University of Bologna, Italy

Received 18 July 2005 ,Accepted 21 September 2005.

References 

  1. Di Tullio M, Sacco RL, Gopal A, et al. Patent foramen ovale as a risk factor for cryptogenic stroke. Ann Intern Med. 1992;117:461–465
  2. Lamy C, Giannesini C, Zuber M, et al. Clinical and imaging findings in cryptogenic stroke patients with and without patent foramen ovale: the PFO-ASA study. Stroke. 2002;33:706–711
  3. Kerut EK, Norfleet WT, Plotnick GD, et al. Patent foramen ovale: a review of associated conditions and the impact of physiological size. J Am Coll Cardiol. 2001;38:613–623
  4. Wilmshurst PT, Nightingale S, Walsh KP, et al. Effect on migraine of closure of cardiac right-to-left shunts to prevent recurrence of decompression illness or stroke or for hemodynamic reasons. Lancet. 2000;356:1648–1651
  5. Wilmshurst P, Nightingale S. Relationship between migraine and cardiac and pulmonary right-to-left shunts. Clin Sci. 2001;100:215–220
  6. Sztajzel R, Genoud D, Roth S, et al. Patent foramen ovale, a possible cause of symptomatic migraine: a study of 74 patients with acute cerebral ischemic stroke. Cerebrovasc Dis. 2002;13:102–106
  7. Anzola GP, Magoni M, Guindani M, et al. Potential source of cerebral embolism in migraine with aura: a transcranial Doppler study. Neurology. 1999;52:1622–1625
  8. Del sette M, Angeli S, Leandri M, et al. Migraine with aura and right-to-left shunt on transcranial Doppler: a case-control study. Cerebrovasc Dis. 1998;8:327–330
  9. Schwerzmann M, Wiher S, Nedeltchev K, et al. Percutaneous closure of patent foramen ovale reduces the frequency of migraine attacks. Neurology. 2004;62:1399–1401
  10. Reisman M, Christofferson RD, Jesurum J, et al. Migraine headache relief after transcatheter closure of patent foramen ovale. J Am Coll Cardiol. 2005;45:493–495
  11. Giardini A, Donti A, Formigari R, et al. Comparison of results of percutaneous closure of patent foramen ovale for paradoxical embolism in patients with versus without thrombophilia. Am J Cardiol. 2004;94:1012–1016
  12. Whindecker S, Wahl A, Chatterjee T, et al. Percutaneous closure of patent foramen ovale in patients with paradoxical embolism. Circulation. 2000;101:893–898
  13. Olivares-Reyes A, Chan S, Lazar EJ, et al. Atrial septal aneurysm: a new classification in two hundred five adults. J Am Soc Echocardiogr. 1997;10:644–656
  14. Anzai H, Child J, Natterson B, et al. Incidence of thrombus formation on the CardioSEAL and the Amplatzer interatrial closure devices. Am J Cardiol. 2004;93:426–431
  15. Moehring MA, Spencer MP. Power M-mode Doppler for observing cerebral blood flow and tracking emboli. Ultrasound Med Biol. 2002;28:49–57
  16. Stewart WF, Lipton RB, Dowson AJ, et al. Development and testing of the Migraine Disability Assessment (MIDAS) questionnaire to assess headache-related disability. Neurology. 2001;56:S20–S28
  17. Lipton RB, Stewart WF, Sawyer J, et al. Clinical utility of an instrument assessing migraine disability: the Migraine Assessment (MIDAS) questionnaire. Headache. 2001;41:854–861
  18. Donti A, Giardini A, Formigari A, et al. Transcatheter coil occlusion of residual shunt in patient with recurrent cryptogenic stroke after PFO percutaneous closure. Catheter Cardiovasc Interv. 2004;61:415–417
  19. Azarbal B, Tobis J, Suh W, et al. Association of interatrial shunts and migraine headaches. J Am Coll Cardiol. 2005;45:489–492

PII: S0002-8703(05)00875-6

doi: 10.1016/j.ahj.2005.09.019

American Heart Journal
Volume 151, Issue 4 , Pages 922.e1-922.e5 , April 2006

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