American Heart Journal
Volume 151, Issue 3 , Pages 553-555 , March 2006

A salty salute: Progenitor cell therapies and no-option heart disease

  • Cam Patterson, MD

      Affiliations

    • Corresponding Author InformationReprint requests: Cam Patterson, MD, Director, Division of Cardiology and Carolina Cardiovascular Biology Center, University of North Carolina at Chapel Hill, 8200 Medical Biomolecular Research Building, Chapel Hill, NC 27599-7126.

Received 9 May 2005 ,Accepted 10 May 2005.

References 

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  2. Orlic D, Kajstura J, Chimenti S, et al. Bone marrow cells regenerate infarcted myocardium. Nature. 2001;410:701–705
  3. Balsam LB, Wagers AJ, Christensen JL, et al. Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium. Nature. 2004;428:668–673
  4. Murry CE, Soonpaa MH, Reinecke H, et al. Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature. 2004;428:664–668
  5. Tse HF, Kwong YL, Chan JK, et al. Angiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation. Lancet. 2003;361:47–49
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  7. Perin EC, Dohmann HF, Borojevic R, et al. Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure. Circulation. 2003;107:2294–2302
  8. Fuchs S, Satler LF, Kornowski R, et al. Catheter-based autologous bone marrow myocardial injection in no-option patients with advanced coronary artery disease: a feasibility study. J Am Coll Cardiol. 2003;41:1721–1724
  9. Losordo DW, Vale PR, Hendel RC, et al. Phase 1/2 placebo-controlled, double-blind, dose-escalating trial of myocardial vascular endothelial growth factor 2 gene transfer by catheter delivery in patients with chronic myocardial ischemia. Circulation. 2002;105:2012–2018
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 Work in the author's laboratory is supported by NIH grants GM61728, HL65619, AG02482, and HL61656. CP is an established investigator of the American Heart Association and a Burroughs Wellcome Fund Clinical Scientist in Translational Research.

PII: S0002-8703(05)00504-1

doi: 10.1016/j.ahj.2005.05.009

American Heart Journal
Volume 151, Issue 3 , Pages 553-555 , March 2006

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