American Heart Journal
Volume 150, Issue 4 , Pages 617-619 , October 2005

Treating depression after myocardial infarction: Can selecting patients on the basis of genetic susceptibility improve psychiatric and medical outcomes?

  • Redford B. Williams, MD

      Affiliations

    • Corresponding Author InformationReprint requests: Redford B. Williams, MD, Duke University Medical Center, Box 3926, Durham, NC 27710.

Received 11 April 2005 ,Accepted 29 April 2005.

References 

  1. Writing Committee for the ENRICHD Investigators . Effects of treating depression and low perceived social support on clinical events after myocardial infarction. The Enhancing Recovery in Coronary Heart Disease patients (ENRICHD) randomized trial. JAMA. 2003;289:3106–3116
  2. Glassman AH, O'Conner CM, Califf RM, et al. Sertraline treatment of major depression in patients with acute MI or unstable angina. JAMA. 2002;288:701–709
  3. Nakatani D, Sata H, Sakata Y, et al. Influence of serotonin transporter gene polymorphism on depressive symptoms and new cardiac events after acute myocardial infarction. Am Heart J. 2005;150:652–658
  4. Caspi A, Sugden K, Moffitt TE, et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science. 2003;301:386–389
  5. Hance M, Carney RM, Freedland KE, et al. Depression in patients with coronary heart disease: a 12-month follow-up. Gen Hosp Psychiatry. 1996;18:61–65
  6. Lesperance F, Frasure-Smith N, Talajic M. Major depression before and after myocardial infarction: its nature and consequences. Psychosom Med. 1996;58:99–110
  7. Bishop GD, Kaur D, Tan VLM. Effects of a psychosocial skills training workshop on psychophysiological and psychosocial risk in patients undergoing coronary artery bypass grafting. Am Heart J. 2005;150:602–609
  8. Coto E, Reguero JR, Alvarez V, et al. 5-Hydroxytryptamine 5-HT2A receptor and 5-hydroxytryptamine transporter polymorphisms in acute myocardial infarction. Clin Sci. 2003;104:241–245
  9. Williams RB, Marchuk DA, Gadde KM, et al. Central nervous system serotonin function and cardiovascular responses to stress. Psychosom Med. 2001;63:300–305
  10. Gelernter J, Cubells JF, Kidd JR, et al. Population studies of polymorphisms of the serotonin transporter gene. Am J Med Genet (Neuropsychiatr Genet). 1999;88:61–66
  11. Smeraldi E, Zanardi R, Fenedetti F, et al. Polymorphism within the promoter of the serotonin transporter gene and antidepressant efficacy of fluvoxamine. Mol Psychiatry. 1998;3:508–511

 Redford Williams is a founder and major stockholder of Williams LifeSkills, Inc, a company whose mission is to develop, test, and market behavioral interventions to reduce stress and anger.

PII: S0002-8703(05)00448-5

doi: 10.1016/j.ahj.2005.04.028

American Heart Journal
Volume 150, Issue 4 , Pages 617-619 , October 2005

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