American Heart Journal
Volume 150, Issue 2 , Pages 220.e1-220.e5 , August 2005

A randomized trial comparing clopidogrel versus ticlopidine therapy in patients undergoing infarct artery stenting for acute myocardial infarction with abciximab as adjunctive therapy

  • Guido Parodi, MD, PhD, FESC

      Affiliations

    • Division of Cardiology, Careggi Hospital, Florence, Italy
    • Corresponding Author InformationReprint requests: Guido Parodi, MD, PhD, FESC, Division of Cardiology, Careggi Hospital, Viale Morgagni 85, I-50134, Florence, Italy.
    • ,
  • Roberto Sciagrà, MD

      Affiliations

    • Nuclear Medicine Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    • ,
  • Angela Migliorini, MD

      Affiliations

    • Division of Cardiology, Careggi Hospital, Florence, Italy
    • ,
  • Gentian Memisha, MD

      Affiliations

    • Division of Cardiology, Careggi Hospital, Florence, Italy
    • ,
  • Guia Moschi, MD

      Affiliations

    • Division of Cardiology, Careggi Hospital, Florence, Italy
    • ,
  • Renato Valenti, MD

      Affiliations

    • Division of Cardiology, Careggi Hospital, Florence, Italy
    • ,
  • Alberto Pupi, MD

      Affiliations

    • Nuclear Medicine Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    • ,
  • David Antoniucci, MD

      Affiliations

    • Division of Cardiology, Careggi Hospital, Florence, Italy

Received 14 February 2005 ,Accepted 7 April 2005.

References 

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  2. Antoniucci D, Rodriguez A, Hempel A, et al. A randomized trial comparing primary infarct artery stenting with or without abciximab in acute myocardial infarction. J Am Coll Cardiol. 2003;42:1879–1885
  3. Klinkhardt U, Bauersachs R, Adams J, et al. Clopidogrel but not aspirin reduces P-selectin expression and formation of platelet-leukocyte aggregates in patients with atherosclerotic vascular disease. Clin Pharmacol Ther. 2003;73:232–241
  4. Klinkhardt U, Graff J, Harder S. Clopidogrel, but not abciximab, reduces platelet leukocyte conjugates and P-selectin expression in a human ex vivo in vitro model. Clin Pharmacol Ther. 2002;71:176–185
  5. Fredrickson BJ, Turner NA, Kleiman KS, et al. Effects of abciximab, ticlopidine and combined abciximab/ticlopidine therapy in platelet and leukocyte function in patients undergoing coronary angioplasty. Circulation. 2000;101:1122–1129
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  8. Sciagrà R, Imperiale A, Antoniucci D, et al. Relationship of infarct size and severity versus left ventricular ejection fraction and volumes obtained from 99mTc-sestamibi gated single-photon emission computed tomography in patients treated with primary percutaneous coronary intervention. Eur J Nucl Med Mol Imaging. 2004;31:969–974
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  11. Antoniucci D, Migliorini A, Parodi G, et al. Abciximab-supported infarct artery stent implantation for acute myocardial infarction and long-term survival. A prospective multicenter randomised trial comparing infarct artery stenting plus abciximab with stenting alone. Circulation. 2004;109:1704–1706
  12. Santoro GM, Valenti R, Buonamici P, et al. Relation between ST-segment changes and myocardial perfusion evaluated by myocardial contrast echocardiography in patients with acute myocardial infarction treated with direct angioplasty. Am J Cardiol. 1998;82:932–937
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  14. Bertrand ME, Rupprecht H-J, Urban P, et al. for the CLASSICS Investigators Double-blind study of the safety of clopidogrel with and without a loading dose in combination with aspirin compared with ticlopidine in combination with aspirin after coronary stenting: the Clopidogrel Aspirin Stent International Cooperative Study (CLASSICS). Circulation. 2000;102:624–629
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  18. Mehta SR, Yusuf S, Peters RJ, et al. for the Clopidogrel in Unstable angina to prevent Recurrent Events trial (CURE) Investigators  Effects of pretreatment with clopidogrel and aspirin followed by long term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study. Lancet. 2001;358:527–533
  19. Steinhubl SR, Berger PB, Mann JT, et al. for the CREDO Investigators Clopidogrel for the reduction of events during observation. Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial. JAMA. 2002;288:2411–2420

 This study was supported by a research grant from the ARCARD ONLUS Foundation, Florence, Italy.

PII: S0002-8703(05)00387-X

doi: 10.1016/j.ahj.2005.04.010

American Heart Journal
Volume 150, Issue 2 , Pages 220.e1-220.e5 , August 2005

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