American Heart Journal
Volume 150, Issue 5 , Pages 977-982 , November 2005

Diastolic dysfunction after mediastinal irradiation

  • Paul A. Heidenreich, MD

      Affiliations

    • Cardiology Section, VA Palo Alto Health Care System, Stanford University, Stanford, Calif
    • Department of Medicine, Stanford University, Stanford, Calif
    • Corresponding Author InformationReprint requests: Paul A. Heidenreich, MD, 111C Cardiology, Palo Alto VA Health Care System, 3801 Miranda Avenue, Palo Alto, CA 94034.
    • ,
  • Steven L. Hancock, MD

      Affiliations

    • Department of Radiation Oncology, Stanford University, Stanford, Calif
    • ,
  • Randall H. Vagelos, MD

      Affiliations

    • Department of Medicine, Stanford University, Stanford, Calif
    • ,
  • Byron K. Lee, MD

      Affiliations

    • Department of Medicine, University of California at San Francisco, San Francisco, Calif
    • ,
  • Ingela Schnittger, MD

      Affiliations

    • Department of Medicine, Stanford University, Stanford, Calif

Received 28 June 2004 ,Accepted 17 December 2004.

References 

  1. Applefeld MM, Slawson RG, Spicer KM, et al. Long-term cardiovascular evaluation of patients with Hodgkin's disease treated by thoracic mantle radiation therapy. Cancer Treat Rep. 1982;66:1003–1013
  2. Stewart JR, Fajardo LF. Radiation-induced heart disease: an update. Prog Cardiovasc Dis. 1984;27:173–194
  3. Heidenreich PA, Hancock SL, Lee BK, et al. Asymptomatic cardiac disease following mediastinal irradiation. J Am Coll Cardiol. 2003;42:743–749
  4. Warda M, Khan A, Massumi A, et al. Radiation-induced valvular dysfunction. J Am Coll Cardiol. 1983;2:180–185
  5. McEniery PT, Dorosti K, Schiavone WA, et al. Clinical and angiographic features of coronary artery disease after chest irradiation. Am J Cardiol. 1987;60:1020–1024
  6. King V, Constine LS, Clark D, et al. Symptomatic coronary artery disease after mantle irradiation for Hodgkin's disease. Int J Radiat Oncol Biol Phys. 1996;36:881–889
  7. Hancock SL, Tucker MA, Hoppe RT. Factors affecting late mortality from heart disease after treatment of Hodgkin's disease. JAMA. 1993;270:1949–1955
  8. Redfield MM, Jacobsen SJ, Burnett JC, et al. Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic. JAMA. 2003;289:194–202
  9. Sahn DJ, DeMaria A, Kisslo J, et al. Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. Circulation. 1978;58:1072–1083
  10. Devereux RB, Alonso DR, Lutas EM, et al. Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings. Am J Cardiol. 1986;57:450–458
  11. Blackburn H, Keys A, Simonson E. The electrocardiogram in population studies. A classification system. Circulation. 1960;21:1160–1175
  12. Geleijnse ML, Fioretti PM, Roelandt JR. Methodology, feasibility, safety and diagnostic accuracy of dobutamine stress echocardiography. J Am Coll Cardiol. 1997;30:595–606
  13. Vasan RS, Benjamin EJ, Levy D. Prevalence, clinical features and prognosis of diastolic heart failure: an epidemiologic perspective. J Am Coll Cardiol. 1995;26:1565–1574
  14. Kreuser ED, Voller H, Behles C, et al. Evaluation of late cardiotoxicity with pulsed Doppler echocardiography in patients treated for Hodgkin's disease. Br J Haematol. 1993;84:615–622
  15. Lund MB, Ihlen H, Voss BM, et al. Increased risk of heart valve regurgitation after mediastinal radiation for Hodgkin's disease: an echocardiographic study. Heart. 1996;75:591–595
  16. Glanzmann C, Huguenin P, Lutolf UM, et al. Cardiac lesions after mediastinal irradiation for Hodgkin's disease. Radiother Oncol. 1994;30:43–54
  17. Bella JN, Palmieri V, Roman MJ, et al. Mitral ratio of peak early to late diastolic filling velocity as a predictor of mortality in middle-aged and elderly adults: the Strong Heart Study. Circulation. 2002;105:1928–1933

 The study was supported by grant 1 RO1 CA 63001 from the National Cancer Institute, National Institutes of Health. PAH is supported by a Career Development Award from the Veteran's Affairs Health Services Research Development Office.

PII: S0002-8703(05)00028-1

doi: 10.1016/j.ahj.2004.12.026

American Heart Journal
Volume 150, Issue 5 , Pages 977-982 , November 2005

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