American Heart Journal
Volume 148, Issue 6 , Pages 1068-1078 , December 2004

Challenges in the conduct of large simple trials of important generic questions in resource-poor settings: The CREATE and ECLA trial program evaluating GIK (glucose, insulin and potassium) and low-molecular-weight heparin in acute myocardial infarction

  • Salim Yusuf, DPhil, FRCPC

      Affiliations

    • Department of Medicine, McMaster University, and Population Health Research Institute (PHRI), Hamilton General Hospital, McMaster University, Hamilton, Canada
    • Corresponding Author InformationReprint requests: Salim Yusuf, DPhil, FRCPC, Population Health Research Institute, Hamilton General Hospital and McMaster University, 237 Barton Street East, Hamilton, Ontario, Canada L8L 2X2.
    • ,
  • Shamir R. Mehta, MD, MSc, FRCPC, FACC

      Affiliations

    • Department of Medicine, McMaster University, and Population Health Research Institute (PHRI), Hamilton General Hospital, McMaster University, Hamilton, Canada
    • ,
  • Rafael Díaz, MD

      Affiliations

    • Estudios Clínicos LatinoAmerica (ECLA), and the Department of Cardiology, Instituto Cardiovascular de Rosario (ICR), Rosario, Santa Fe, Argentina
    • ,
  • Ernesto Paolasso, MD

      Affiliations

    • Estudios Clínicos LatinoAmerica (ECLA), and the Department of Cardiology, Instituto Cardiovascular de Rosario (ICR), Rosario, Santa Fe, Argentina
    • ,
  • Prem Pais, MBBS

      Affiliations

    • St. John's Medical College and the Division of Clinical Research, Institute of Population Health and Clinical Research, St. John's National Academy of Health Sciences, Bangalore, India
    • ,
  • Denis Xavier, MBBS

      Affiliations

    • St. John's Medical College and the Division of Clinical Research, Institute of Population Health and Clinical Research, St. John's National Academy of Health Sciences, Bangalore, India
    • ,
  • Changchun Xie, PhD

      Affiliations

    • Population Health Research Institute (PHRI), McMaster University, Hamilton, Canada
    • ,
  • Rashid J. Ahmed, BScH

      Affiliations

    • Population Health Research Institute (PHRI), McMaster University, Hamilton, Canada
    • ,
  • Khawar Khazmi, MBBS

      Affiliations

    • Cardiology Section, Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan
    • ,
  • Jun Zhu, MD

      Affiliations

    • Fu Wai Hospital, Beijing, China
    • ,
  • Lisheng Liu, MD

      Affiliations

    • Cardiovascular Institute and Fu Wai Hospital (CAMS), and Clinical Trials and Research Centre, Chinese Hypertension League Institute, Beijing, China
    • ,
  • CREATE-ECLA Investigators and Steering Committee

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☆ Salim Yusuf is supported by an Endowed Chair of the Heart and Stroke Foundation of Ontario and a Senior Scientist Award from the Canadian Institutes of Health Research (CIHR). Shamir R. Mehta is supported by a CIHR New Investigator award.

PII: S0002-8703(04)00593-9

doi: 10.1016/j.ahj.2004.08.033

American Heart Journal
Volume 148, Issue 6 , Pages 1068-1078 , December 2004

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