American Heart Journal
Volume 149, Issue 5 , Pages 840-845 , May 2005

Microalbuminuria: A strong predictor of 3-year adverse prognosis in nondiabetic patients with acute myocardial infarction

  • Spyridon Koulouris, MD, PhD

      Affiliations

    • 1st Cardiology Department, “Evangelismos Hospital,” Athens, Greece
    • Corresponding Author InformationReprint requests: Spyridon N. Koulouris, MD, PhD, Kekropos 64, 151 25 Marousi, Athens, Greece.
    • ,
  • Ioannis Lekatsas, MD, PhD

      Affiliations

    • 1st Cardiology Department, “Evangelismos Hospital,” Athens, Greece
    • ,
  • Ilias Karabinos, MD, PhD

      Affiliations

    • 1st Cardiology Department, “Evangelismos Hospital,” Athens, Greece
    • ,
  • Georgios Ioannidis, MD, PhD

      Affiliations

    • Department of Endocrinology, Diabetes and Metabolism, “Evangelismos Hospital,” Athens, Greece
    • ,
  • Theofanis Katostaras, PhD

      Affiliations

    • Faculty of Nursing, University of Athens, Athens, Greece
    • ,
  • Athanasios Kranidis, MD, PhD

      Affiliations

    • 1st Cardiology Department, “Evangelismos Hospital,” Athens, Greece
    • ,
  • Konstantinos Triantafillou, MD

      Affiliations

    • 1st Cardiology Department, “Evangelismos Hospital,” Athens, Greece
    • ,
  • Nikolaos Thalassinos, MD, PhD

      Affiliations

    • Department of Endocrinology, Diabetes and Metabolism, “Evangelismos Hospital,” Athens, Greece
    • ,
  • Lambros Anthopoulos, MD, PhD

      Affiliations

    • Athens Medical Center, Athens, Greece

Received 14 March 2004 ,Accepted 27 July 2004.

References 

  1. Viberti GC, Hill RD, Jarrett RJ, et al. Microalbuminuria as a predictor of clinical nephropathy in insulin-dependent diabetes mellitus. Lancet. 1982;1:1430–1432
  2. Mogensen CE, Christensen CK. Predicting diabetic nephropathy in insulin-dependent patients. N. Engl. J. Med. 1984;311:89–93
  3. Mogensen CE. Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. N. Engl. J. Med. 1984;310:356–360
  4. Weis U, Turner B, Gibney J, et al. Long-term predictors of coronary artery disease and mortality in type 1 diabetes. QJM. 2001;94:623–630
  5. Mattock MB, Barnes DJ, GianCarlo V, et al. Microalbuminuria and coronary heart disease in NIDDM. An incidence study. Diabetes. 1998;47:1786–1792
  6. McGuire DK. Influence of proteinuria on long-term outcome among patients with diabetes: the evidence continues to accumulate. Am. Heart J. 2000;139:934–935
  7. Jager A, Kostense PJ, Ruhe HG, et al. Microalbuminuria and peripheral arterial disease are predictors of cardiovascular and all-cause mortality, especially among hypertensive subjects. Five-year follow-up of the Hoorn study. Arterioscler. Thromb. Vasc. Biol. 1999;19:617–624
  8. Mykkaanen L, Zaccaro DJ, Wagenknecht LE, et al. Microalbuminuria is associated with insulin resistance in non-diabetic subjects. The Insulin Resistance Atherosclerosis Study. Diabetes. 1998;47:793–800
  9. Krentz AJ. Insulin resistance in clinical medicine. In:  Krentz AJ editors. Insulin resistance: a clinical handbook. Cambridge: Blackwell Science; 2002;p. 73
  10. Hillege HL, Janssen WMT, Bak AAA, et al. Microalbuminuria is common, also in a nondiabetic, nonhypertensive population, and an independent indicator of cardiovascular risk factors and cardiovascular morbidity. J. Intern. Med. 2001;249:519–526
  11. Klausen K, Borch-Johnsen K, Feldt-Rasmussen B, et al. Very low levels of microalbuminuria are associated with increased risk of coronary heart disease and death independently of renal function, hypertension and diabetes. Circulation. 2004;110:32–35
  12. Berton G, Cordiano R, Mbaso S, et al. Prognostic significance of hypertension and albuminuria for early mortality after acute myocardial infarction. J. Hypertens. 1998;16:525–530
  13. Berton G, Cordiano R, Palmieri R, et al. Microalbuminuria during acute myocardial infarction. A strong predictor for 1-year mortality. Eur. Heart J. 2001;22:1466–1475
  14. Gensini GG. Coronary arteriography. In: Mt. Kisco (NY): Futura; 1975;p. 488
  15. Rossing P, Hougaard P, Borch-Johnsen K, et al. Predictors of mortality in insulin dependent diabetes: 10 year observational follow up study. BMJ. 1996;313:779–784
  16. Neil A, Hawking M, Potok M, et al. A prospective population-based study of microalbuminuria as a predictor of mortality in NIDDM. Diabetes Care. 1993;16:996–1003
  17. Romunsdstad S, Holmen J, Hallan H, et al. Microalbuminuria and all-cause mortality in treated hypertensive individuals. Does sex matter? The Nord-Trøndelag Health Study (HUNT), Norway. Circulation. 2003;108:2783–2789
  18. Marso SP, Ellis SG, Gurm HS, et al. Proteinuria is a key determinant of death in patients with diabetes after isolated coronary artery bypass grafting. Am. Heart J. 2000;139:939–944
  19. Borch-Johnsen K, Feld-Rasmussen B, Strangaard S, et al. Urinary albumin excretion. An independent predictor of ischemic heart disease. Arterioscler. Thromb. Vasc. Biol. 1999;19:1992–1997
  20. Gerstein HC, Mann JFE, Qilong Y, et al. Albuminuria and risk of cardiovascular events, death and heart failure in diabetic and nondiabetic individuals. JAMA. 2001;286:421–426
  21. Gruden G, Cavallo-Perin P, Bazzan M, et al. PAI-1 and factor VII activity are higher in IDDM patients with microalbuminuria. Diabetes. 1994;43:426–429
  22. Kario K, Matsuo T, Kobayashi H, et al. Activation of tissue factor-induced coagulation and endothelial dysfunction in non-insulin dependent diabetic patients with microalbuminuria. Arterioscler. Thromb. Vasc. Biol. 1995;15:1114–1120
  23. Lim SC, LoGerfo FW, Caballero AE, et al. Soluble intercellular adhesion molecule (ICAM-1), vascular cell adhesion molecule (VCAM-1) and impaired microvascular reactivity are early markers of vasculopathy in type-2 diabetic individuals without microalbuminuria. Diabetes Care. 1999;22:1865–1870
  24. Pedrinelli R, Giampietro O, Carmassi F, et al. Microalbuminuria and endothelial dysfunction in essential hypertension. Lancet. 1994;344:14–18
  25. Stehouwer CD, Gall MA, Twisk JW, et al. Increased urinary albumin excretion, endothelial dysfunction and chronic low-grade inflammation in type 2 diabetes: progressive, interrelated and independently associated with risk of death. Diabetes. 2002;51:1157–1165
  26. Nathan DM, Lachin J, Cleary P, et al. The Diabetes Control and Complication Trial/Epidemiology of Diabetes Interventions and Complications Research Group Intensive diabetes therapy and carotid intima-media thickness in type 1 diabetes mellitus. N. Engl. J. Med. 2003;48:2294–2303
  27. Feld-Rasmussen B, Dinesen B, Deckert M. Enzyme immunoassay: an improved determination of urinary albumin in diabetics with incipient nephropathy. Scand. J. Clin. Lab. Invest. 1985;45:539–544

PII: S0002-8703(04)00543-5

doi: 10.1016/j.ahj.2004.07.031

American Heart Journal
Volume 149, Issue 5 , Pages 840-845 , May 2005

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