American Heart Journal
Volume 148, Issue 6 , Pages 937-943 , December 2004

Efficacy and safety of abciximab on acute myocardial infarction treated with percutaneous coronary interventions: A meta-analysis of randomized, controlled trials

  • João Otávio de Queiroz Fernandes Araújo, MD

      Affiliations

    • VOTCOR – Hospital da Venerável Ordem Terceira da Penitência, Rio de Janeiro, Brazil
    • Corresponding Author InformationReprint requests: Dr. João Otávio de Araújo, Hospital da Venerável Ordem Terceira da Penitência VOTCOR, Rua Conde de Bonfim 1033, Tijuca, Rio de Janeiro RJ20530-001, Brazil,
    • ,
  • Henrique Horta Veloso, MD, ScD

      Affiliations

    • VOTCOR – Hospital da Venerável Ordem Terceira da Penitência, Rio de Janeiro, Brazil
    • ,
  • Joyce Morgana Braga De Paiva, MD

      Affiliations

    • VOTCOR – Hospital da Venerável Ordem Terceira da Penitência, Rio de Janeiro, Brazil
    • ,
  • Mohamed Wafae Filho, MD

      Affiliations

    • VOTCOR – Hospital da Venerável Ordem Terceira da Penitência, Rio de Janeiro, Brazil
    • ,
  • Angelo Amato Vincenzo De Paola, MD, ScD

      Affiliations

    • Department of Cardiology, Escola Paulista de Medicina – Universidade Federal de São Paulo, São Paulo, Brazil

Received 5 February 2004 ,Accepted 18 May 2004.

References 

  1. Zhu MN, Feit A, Chadow H, et al.  Primary stent implantation compared with primary angioplasty for acute myocardial infarction: a meta–analysis of randomized trials. Am J Cardiol. 2001;88:297–301
  2. Michaels AD, Gibson CM, Baron HV. Microvascular dysfunction in acute myocardial infarction: focus on the roles of platelet and inflammatory mediators in the no–reflow phenomenon. Am J Cardiol. 2000;85:50B–60B
  3. Ito H, Tomooka T, Sakai N, et al.  Lack of myocardial perfusion immediately after successful thrombolysis: a predictor of poor recovery of left ventricular function in anterior myocardial infarction. Circulation. 1992;85:1699–1705
  4. Azar RR, McKay RG, Thompson PD, et al.  Abciximab in primary coronary angioplasty for acute myocardial infarction improves short– and medium–term outcomes. J Am Coll Cardiol. 1998;32:1996–2002
  5. The EPISTENT Investigators . Randomized placebo–controlled and balloon–angioplasty–controlled trial to assess safety of coronary stenting with use of platelet glycoprotein IIb/IIIa blockade: Evaluation of Platelet IIb/IIIa Inhibitor for Stenting. Lancet. 1998;325:87–92
  6. The EPIC Investigators . Use of monoclonal antibody directed against the platelet glycoprotein IIb/IIIa receptor in high–risk coronary angiography: the EPIC Investigation. N Engl J Med. 1994;330:956–961
  7. Shömig A, Kastrati A, Dirschinger J, et al.  Coronary stenting plus glycoprotein IIb/IIIa blockade compared with tissue plasminogen activator in acute myocardial infarction: stent versus thrombolysis for occluded coronary arteries in patients with acute myocardial infarction study investigators. N Engl J Med. 2000;343:385–391
  8. Giri S, Mitchel JF, Hirst JA, et al.  Synergy between intracoronary stenting and abciximab in acute myocardial infarction. Am J Cardiol. 2000;86:269–274
  9. Eisenberg MJ, Jamal S. Glycoprotein IIb/IIIa inhibition in the setting of acute ST–segment elevation myocardial infarction. J Am Coll Cardiol. 2003;42:1–6
  10. Topol EJ, Neumann FJ, Montalescot G. A preferred reperfusion strategy for acute myocardial infarction. J Am Coll Cardiol. 2003;42:1886–1889
  11. Araújo JO, Veloso HH, Paiva JM. Mortality and reinfarction reduction with primary stent implantation compared with primary balloon angioplasty. Am J Cardiol. 2002;90:1043–1044
  12. The EPILOG Investigators . Platelet glycoprotein IIb/IIIa receptor blockade and low–dose heparin during percutaneous coronary revascularization. N Engl J Med. 1997;336:1689–1696
  13. Brener SJ, Barr LA, Burchenal JEB, et al.  on behalf of the ReoPro and Primary PTCA Organization and Randomized Trial (RAPPORT) Investigators   Randomized, placebo–controlled trial of platelet glycoprotein IIb/IIIa blockade with primary angioplasty for acute myocardial infarction. Circulation. 1998;98:734–741
  14. Neumann FJ, Kastrati A, Schimitt C, et al.  Effect of glycoprotein IIb/IIIa blockade with abciximab on clinical and angiographic restenosis rate after the placement of coronary stents following acute myocardial infarction. J Am Coll Cardiol. 2000;35:915–921
  15. Montalescot G, Barragan P, Wittemberg O, et al.  ADMIRAL Investigators   Platelet glycoprotein IIb/IIIa inhibition with coronary stenting for acute myocardial infarction. N Engl J Med. 2001;344:1895–1903
  16. Petronio AS, Musumeci G, Limbruno U, et al.  Abciximab improves 6–month clinical outcome after rescue coronary angioplasty. Am Heart J. 2002;143:334–341
  17. Stone GW, Grines CL, Cox DA, et al.  Controlled Abciximab and Device Investigation to Lower Late Angioplasty Complications (CADILLAC) Investigators   Comparison of angioplasty with stenting, with or without abciximab, in acute myocardial infarction. N Engl J Med. 2002;346:957–966
  18. Antoniucci D, Rodriguez A, Hempel A, et al.  A randomized trial comparing primary infarct artery stenting with or without abciximab in acute myocardial infarction. J Am Coll Cardiol. 2003;42:1879–1885
  19. Giri S, Mitchel J, Azar RR, et al.  Results of primary percutaneous transluminal coronary angioplasty plus abciximab with or without stenting for acute myocardial infarction complicated by cardiogenic shock. Am J Cardiol. 2002;89:126–131
  20. Chan AW, Chew DP, Bhatt DL, Moliterno DJ, Topol EJ, Ellis SG. Long–term mortality benefit with the combination of stents and abciximab for cardiogenic shock complicating acute myocardial infarction. Am J Cardiol. 2002;89:132–136
  21. Antoniucci D, Valenti R, Migliorini A, et al.  Abciximab therapy improves survival in patients with acute myocardial infarction complicated by early cardiogenic shock undergoing coronary artery stent implantation. Am J Cardiol. 2002;90:353–357
  22. Gibson CM, Cannon CP, Greene RM, et al.  Rescue angioplasty in the thrombolysis in myocardial infarction (TIMI) 4 trial. Am J Cardiol. 1997;80:21–26
  23. The CAPTURE Investigators . Randomized placebo–controlled trial of abciximab before and during coronary intervention in refractory unstable angina: the CAPTURE study. Lancet. 1997;349:1429–1435
  24. Escobar J, Guarda E, Marchant E, Fajuri A, Martínez A, Pichard A. Relation of stenting to decrease coronary blood flow during primary angioplasty in acute myocardial infarction. Am J Cardiol. 2001;88:1410–1412
  25. Neumann FJ, Blasini R, Schmitt C, et al.  Effect of glycoprotein IIb/IIIa receptor blockade on recovery of coronary flow and left ventricular function after the placement of coronary artery stents in acute myocardial infarction. Circulation. 1998;98:2695–2701

PII: S0002-8703(04)00367-9

doi: 10.1016/j.ahj.2004.05.047

American Heart Journal
Volume 148, Issue 6 , Pages 937-943 , December 2004

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