American Heart Journal
Volume 148, Issue 6 , Pages 964-970 , December 2004

Role of central sympathoexcitation in enhanced hypercapnic chemosensitivity in patients with heart failure

  • Kunihiro Yamada, MD

      Affiliations

    • Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
  • ,
  • Hidetsugu Asanoi, MD

      Affiliations

    • Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    • Corresponding Author InformationReprint requests: Hidetsugu Asanoi, MD, Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani Toyama 930-0194, Japan
  • ,
  • Hiroshi Ueno, MD

      Affiliations

    • Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
  • ,
  • Shuji Joho, MD

      Affiliations

    • Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
  • ,
  • Junya Takagawa, MD

      Affiliations

    • Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
  • ,
  • Tomoki Kameyama, MD

      Affiliations

    • Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
  • ,
  • Tadakazu Hirai, MD

      Affiliations

    • Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
  • ,
  • Takashi Nozawa, MD

      Affiliations

    • Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
  • ,
  • Hiroshi Inoue, MD

      Affiliations

    • Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan

Received 9 August 2003 ,Accepted 2 May 2004.

References 

  1. Sullivan MJ, Higginbotham MB, Cobb FR. Increased exercise ventilation in patients with chronic heart failure: intact ventilatory control despite hemodynamic and pulmonary abnormalities. Circulation. 1988;77:552–559
  2. Wada O, Asanoi H, Miyagi K, et al.  Importance of abnormal lung perfusion in excessive exercise ventilation in chronic heart failure. Am Heart J. 1993;125:790–798
  3. Chua TP, Clark AL, Amadi AA, et al.  Relation between chemosensitivity and the ventilatory response to exercise in chronic heart failure. J Am Coll Cardiol. 1996;27:650–657
  4. Chua TP, Harrington D, Ponikowski P, et al.  Effects of dihydrocodeine on chemosensitivity and exercise tolerance in patients with chronic heart failure. J Am Coll Cardiol. 1997;29:147–152
  5. Narkiewicz K, Pesek CA, van de Borne P, et al.  Enhanced sympathetic and ventilatory responses to central chemoreflex activation in heart failure. Circulation. 1999;100:262–267
  6. Ponikowski P, Chua TP, Piepoli M, et al.  Augmented peripheral chemosensitivity as a potential input to baroreflex impairment and autonomic imbalance in chronic heart failure. Circulation. 1997;96:2586–2594
  7. Sasayama S, Asanoi H, Ishizaka S, et al.  Evaluation of functional capacity of patients with congestive heart failure. In:  Yasuda H,  Kawaguchi H editor. New aspects in the treatment of failing heart. Tokyo: Springer-Verlag; 1992;p. 113–117
  8. Read DJC. A clinical method for assessing the ventilatory response to carbon dioxide. Australas Ann Med. 1966;16:20–32
  9. Goso Y, Asanoi H, Ishise H, et al.  Relationship between low-frequency cardiovascular variability and muscle sympathetic nerve activity in patients with cardiac dysfunction. J Cardiovasc Pharmacol. 1999;34(suppl):S63–67
  10. Pagani M, Somers V, Furlan R, et al.  Changes in autonomic regulation induced by physical training in mild hypertension. Hypertension. 1988;12:600–610
  11. Bellville JW, Whipp BJ, Kaufman RD, et al.  Central and peripheral chemoreflex loop gain in normal and carotid body-resected subjects. J Appl Physiol. 1979;46:843–853
  12. Cherniack NS. Respiratory dysrhythmias during sleep. N Engl J Med. 1981;305:325–330
  13. Weil JV, Byrne-Quinn E, Sodal IE, et al.  Augmentation of chemosensitivity during mild exercise in normal human. J Appl Physiol. 1972;33:813–819
  14. Kryger MH, Roth T, Dement WC. Principles and practice of sleep medicine. 2nd ed. Philadelphia: WB Saunders; 1994; p. 204–11
  15. Cherniack NS, von Euler C, Homma I, et al.  Experimentally induced Cheyne-Stokes breathing. Respir Physiol. 1979;37:185–200
  16. Milsom WK, Sadig T. Interaction between norepinephrine and hypoxia on carotid body chemoreception in rabbits. J Appl Physiol. 1983;55:1893–1898
  17. Lambert GW, Kaye DM, Lefkovits J, et al.  Increased central nervous system monoamine neurotransmitter turnover and its association with sympathetic nervous activity in treated heart failure patients. Circulation. 1995;92:1813–1818
  18. Leenen FHH, Huang BS, Yu H, et al.  Brain “ouabain” mediates sympathetic hyperactivity in congestive heart failure. Circ Res. 1995;77:993–1000
  19. Heistad DD, Abboud FM, Mark AL, et al.  Effect of baroreceptor activity on ventilatory response to chemoreceptor stimulation. J Appl Physiol. 1975;39:411–416
  20. Mancia G. Influence of carotic baroreceptors on vascular response to carotid chemoreceptor stimulation in the dog. Circ Res. 1975;36:270–276
  21. Heistad DD, Abboud FM, Mark AL, et al.  Interaction of baroreceptor and chemoreceptor reflexes: modulation of the chemoreceptor reflex by changes in baroreceptor activity. J Clin Invest. 1974;53:1226–1236
  22. Mancia G, Shepherd JT, Donald DE. Interplay among carotid sinus, cardiopulmonary, and carotid body reflexes in dogs. Am J Physiol. 1976;230:19–24
  23. Somers VK, Mark AL, Abboud FM. Interaction of baroreflex and chemoreceptor reflex control of sympathetic nerve activity in normal humans. J Clin Invest. 1991;87:1953–1957
  24. Miura M, Reis DJ. The role of the solitary and paramedian reticular nuclei in mediating cardiovascular reflex responses from carotid baro- and chemoreceptors. J Physiol. 1972;223:525–548
  25. Ma R, Zucker IH, Wang W. Central gain of the cardiac sympa-thetic afferent reflex in dogs with heart failure. Am J Physiol. 1997;273:H2664–2671
  26. Liu J-L, Irvine S, Reid IA, et al.  Chronic exercise reduces sympathetic nerve activity in rabbits with pacing-induced heart failure: a role for angiotensin II. Circulation. 2000;102:1854–1862
  27. Goso Y, Asanoi H, Ishise H, et al.  Respiratory modulation of muscle sympathetic nerve activity in patients with chronic heart failure. Circulation. 2001;104:418–423
  28. Bradley TD, Floras JS. Pathophysiologic and therapeutic implications of sleep apnea in congestive heart failure. J Card Fail. 1996;2:223–240
  29. Javaheri S. A mechanism of central sleep apnea in patients with heart failure. N Engl J Med. 1999;341:949–954
  30. Lang CC, Rayos GH, Chomsky DB, et al.  Effect of sympathoinhibition on exercise performance in patients with heart failure. Circulation. 1997;96:238–245
  31. Coats AJS. Heart failure 99—the MOXCON trial. Int J Cardiol. 1999;71:109–111
  32. Swedberg K, Bristow MR, Cohn JN, et al.  Effects of sustained-release moxonidine, an imidazoline agonist, on plasma norepinephrine in patients with chronic heart failure. Circulation. 2002;105:1797–1803
  33. Gelfand R, Lambertsen CJ. Dynamic respiratory response to abrupt change of inspired CO2 at normal and high PO2. J Appl Physiol. 1973;35:903–913

 Supported by Grant-in-Aid for General Scientific Research No 13670697 from the Ministry of Education, Science and Culture of Japan.

PII: S0002-8703(04)00324-2

doi: 10.1016/j.ahj.2004.05.030

American Heart Journal
Volume 148, Issue 6 , Pages 964-970 , December 2004