American Heart Journal
Volume 148, Issue 3 , Page 530 , September 2004

Acute effects of β-endorphin on cardiovascular function in patients with mild to moderate chronic heart failure

  • Domenico Cozzolino, MD

      Affiliations

    • Department of Geriatrics and Metabolic Diseases, II University of Naples, Naples, Italy
    • Corresponding Author InformationReprint requests: Dr Domenico Cozzolino, via Cozzolino, 116, 80056 - Ercolano (NA), Italy.
    • ,
  • Ferdinando C. Sasso, MD

      Affiliations

    • Department of Geriatrics and Metabolic Diseases, II University of Naples, Naples, Italy
    • ,
  • Teresa Salvatore, MD

      Affiliations

    • Department of Geriatrics and Metabolic Diseases, II University of Naples, Naples, Italy
    • ,
  • Michele Torella, MD

      Affiliations

    • Department of Cardiothoracic Sciences, II University of Naples, Naples, Italy
    • ,
  • Antonio Cittadini, MD

      Affiliations

    • Department of Internal Medicine, Federico II University, Naples, Italy
    • ,
  • Sandro Gentile, MD

      Affiliations

    • Department of Geriatrics and Metabolic Diseases, II University of Naples, Naples, Italy
    • ,
  • Roberto Torella, MD

      Affiliations

    • Department of Geriatrics and Metabolic Diseases, II University of Naples, Naples, Italy
    • ,
  • Dario Giugliano, MD

      Affiliations

    • Department of Geriatrics and Metabolic Diseases, II University of Naples, Naples, Italy

Received 18 October 2003 ,Accepted 13 January 2004.

References 

  1. Atweh SF, Kuhar MJ. Distribution and physiological significance of opioid receptors in the brain. Br Med Bull. 1983;39:47–52
  2. Holaday JW. Cardiovascular effects of the endogenous opiate system. Annu Rev Pharmacol Toxicol. 1983;23:541–594
  3. Holaday JW, Faden AI. Naloxone reversal of endotoxin hypotension suggests role of endorphins in shock. Nature. 1978;275:450–451
  4. Imai N, Kashiki M, Woolf PD, et al.  Comparison of cardiovascular effects of μ- and δ-opioid receptor antagonists in dogs with congestive heart failure. Am J Physiol. 1994;267(Heart Circ Physiol 36):H912–H917
  5. Springhorn JP, Claycomb WC. Translation of heart preproenkephalin mRNA and secretion of enkephalin peptides from cultured cardiac myocytes. Am J Physiol. 1992;263(Heart Circ Physiol 32):H1560–H1566
  6. Caffrey JL, Boluyt MO, Younes A, et al.  Aging, cardiac proenkephalin mRNA and enkephalin peptides in the F344 rat. J Mol Cell Cardiol. 1994;26:701–711
  7. Ventura C, Spurgeon H, Lakatta EG, et al.  κ and δ opioid receptor stimulation affects cardiac myocyte function and Ca2+ release from an intracellular pool in myocytes and neurons. Circ Res. 1992;70:66–81
  8. Francis GS, Goldsmith SR, Levine TB, et al.  The neurohormonal axis in congestive heart failure. Ann Intern Med. 1984;101:370–377
  9. Swedberg K, Eneroth P, Kjekshus J, et al.  for the CONSENSUS Trial Study Group   Hormones regulating cardiovascular function in patients with severe congestive heart failure and relation to mortality. Circulation. 1990;82:1730–1736
  10. Kawashima S, Fukutake N, Nishian K, et al.  Elevated plasma beta-endorphin levels in patients with congestive heart failure. J Am Coll Cardiol. 1991;17:53–58
  11. Sahn DJ, De Maria A, Kissio J, et al.  The committee on M-mode standardization of the American Society of Echocardiography: recommendations regarding quantification in M-mode echocardiography: results of a survey of echocardiography measurements. Circulation. 1978;58:1072–1083
  12. Folland ED, Parisi AF, Moynihan PF, et al.  Assessment of left ventricular ejection fraction and volumes by real-time, two-dimensional echocardiography (a comparison of cineangiographic and radionuclide techniques). Circulation. 1979;60:760–766
  13. Coppola L, Cozzolino D, Giugliano D, et al.  Hemorheological and cardiovascular responses to beta-endorphin and naloxone in healthy subjects and patients with essential hypertension. J Clin Endocrinol Metab. 1994;79:1510–1514
  14. McElroy PA, Janicki JS, Weber KT. Cardiopulmonary exercise testing in congestive heart failure. Am J Cardiol. 1988;62:35A–40A
  15. Lord JAH, Waterfield AA, Hughes J, et al.  Endogenous opioid peptides (multiple agonists and receptors). Nature. 1977;267:495–499
  16. Cozzolino D, Sessa G, Salvatore T, et al.  The involvement of the opioid system in human obesity (a study in normal-weight relatives of obese people). J Clin Endocrinol Metab. 1996;81:713–718
  17. Kienbaum P, Heuter T, Michel MC, et al.  Chronic μ-opioid receptor stimulation in humans decreases muscle sympathetic nerve activity. Circulation. 2001;103:850–855
  18. Gaddis RR, Dixon WR. Modulation of peripheral adrenergic neurotransmission by methionine-enkephalin. J Pharmacol Exp Ther. 1982;221:282–287
  19. Bristow MR. β-Adrenergic receptor blockade in chronic heart failure. Circulation. 2000;101:558–569
  20. Ventura C, Muscari C, Spampinato S, et al.  Inhibitory action of opioid peptides on ouabain-sensitive Na+-K+ and Ca2+ dependent ATPase activities in bovine cardiac sarcolemma. Peptides. 1987;8:709–713
  21. Giugliano D, Salvatore T, Cozzolino D, et al.  Hyperglycaemia and obesity as determinants of glucose, insulin, and glucagon responses to β-endorphin in human diabetes mellitus. J Clin Endocrinol Metab. 1987;64:1122–1128
  22. Sauvadet A, Rohn T, Pecker F, et al.  Synergistic actions of glucagon and miniglucagon on Ca2+ mobilization in cardiac cells. Circ Res. 1996;78:102–109
  23. De Marinis L, Mancini A, Valle D, et al.  Physiological role of the opioid-cholinergic interaction in growth hormone neuroregulation: effect of sex and food intake. Metabolism. 1997;46:740–744
  24. Fazio S, Sabatini D, Capaldo B, et al.  A preliminary study of growth hormone in the treatment of dilated cardiomyopathy. N Engl J Med. 1996;334:809–814
  25. Arendt RM, Schmoeckel M, Wilbert-Lampen U, et al.  Bidirectional effects of endogenous opioid peptides on endothelin release in porcine aortic endothelial cell culture (mediation by delta opioid receptor and opioid receptor antagonist-insensitive mechanisms). J Pharmacol Exp Ther. 1995;272:1–7
  26. Napoli R, Guardasole V, Matarazzo M, et al.  Growth hormone corrects vascular dysfunction in patients with chronic heart failure. J Am Coll Cardiol. 2002;39:90–95
  27. Napoli R, Guardasole V, Angelini V, et al.  Acute effects of growth hormone on vascular function in human subjects. J Clin Endocrinol Metab. 2003;88:2817–2820
  28. Chua TP, Harrington D, Ponikowski P, et al.  Effects of dihydrocodeine on chemosensitivity and exercise tolerance in patients with chronic heart failure. J Am Coll Cardiol. 1997;29:147–152

PII: S0002-8703(04)00190-5

doi: 10.1016/j.ahj.2004.01.029

American Heart Journal
Volume 148, Issue 3 , Page 530 , September 2004

Article Tools