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American Heart Journal
Volume 147, Issue 6
, Pages 956-965
, June 2004
Rhabdomyolysis associated with hydroxymethylglutaryl-coenzyme A reductase inhibitors
References
- Prevention of coronary heart disease with pravastatin in men with hypercholesterolaemia. N Engl J Med. 1995;333:1301–1307
-
Available at: www.ims-global.com. Accessed June 28, 2002
-
Availabel at: http://www.fda.gov/bbs/topics/. Accessed August 28, 2001
-
Fuhrmans V. Bayer discloses higher death toll from Baycol. Wall Street J January 21, 2002;A10
- . Cerivastatin and reports of fatal rhabdomyolysis. N Engl J Med. 2002;346:539–540
- ACC/AHA/NHLBI clinical advisory on the use and safety of statins. J Am Coll Cardiol. 2002;40:567–572
- . The spectrum of rhabdomyolysis. Medicine. 1982;61:141–152
- . Statin-associated myopathy. JAMA. 2003;289:1681–1690
- . Rhabdomyolysis. Am Fam Physician. 2002;65:907–910
- Pravastatin-induced rhabdomyolysis in a patient with mixed connective tissue disease. Arthritis Rheum. 1996;39:1259–1261
- . Learning from the cerivastatin experience. Lancet. 2001;358:1383–1384
- Safety and tolerability of pravastatin in long-term clinical trials (Pravastatin Pooling Project). Circulation. 2002;105:2341–2346
- The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels (CARE study). N Engl J Med. 1996;335:1001–1009
-
LIPID Study group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998;1349–57
- . A coronary primary prevention study of Scottish men aged 45–64 years (trial design). J Clin Epidemiol. 1992;45:849–860
- . Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease (the Scandinavian Simvastatin Survival Study (4S)). Lancet. 1994;344:1383–1389
- Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels (results of AFCAPS/TexCAPS). JAMA. 1998;279:1615–1622
-
.
Withdrawal of cerivastatin from the world market.
Curr Control Trials Cardiovasc Med. 2001;2:205–207
-
.
Cerivastatin in the treatment of mixed hyperlipidemia (the RIGHT study).
Am J Cardiol. 1998;82:47–51J
- Efficacy and safety of cerivastatin, 0.2mg and 0.4mg, in patients with primary hypercholesterolemia (a multinational, randomized, double blind study). Curr Med Res Opin. 1999;15:228–240
- . Rhabdomyolysis and renal failure associated with cerivastatin-gemfibrozil combination therapy. Am J Cardiol. 1999;84:497
-
Available at: http://www.docguide.com/news/content.nsf/NewsPrint/. Accessed August 30, 2001
-
Available at: http://www.docguide.com/dg.nsf/PrintPrint/. Accessed August 28, 2001
- . Rhabdomyolysis due to cerivastastin monotherapy. Am J Med. 2001;110:742
- . Regulation of the mevalonate pathway. Nature. 1990;343:425–430
- New insights into the pharmacodynamic and pharmacokinetic properties of statins. Pharmacol Ther. 1999;84:413–428
- . Mechanism of action and biological profile of HMG CoA reductase inhibitors. Drugs. 1998;36(Suppl 3):72–82
- . HMG CoA reductase inhibitors (current clinical experience). Drugs. 1988;36(Suppl 3):83–86
- . New developments in lipid-lowering therapy (the role of inhibitors of hydroxymethylglutaryl-coenzyme A reductase). Circulation. 1987;76:534–538
-
.
Lipid-lowering drugs and atherosclerosis.
In:
Brody TM editors. Human pharmacology (molecular to clinical. 3rd ed.). St. Louis: Mosby; 1998;p. 286–294
-
Absolute and relative bioavailability of the HMG-CoA reductase inhibitor cerivastatin.
Int J Clin Pharm Ther. 1997;35:255–260
- . Preclinical and clinical pharmacology of rosuvastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor. Am J Cardiol. 2001;87:28–32B
-
.
Preclinical safety evaluation of cerivastatin, a novel HMG-CoA reductase inhibitor.
Am J Cardiol. 1998;82:7J–11
- Inhibition of cholesterol synthesis by squalene synthase inhibitors does not induce myotoxicity in vitro. Toxicol Appl Pharmacol. 1997;145:91–98
- Intraoperative rhabdomyolysis in a patient receiving pravastatin, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitor. Anesth Analg. 1995;81:1089–1091
-
Decreases in serum ubiquinone concentrations do not result in reduced levels in muscle tissue during short-term simvastatin treatment in humans.
Pharmacol Ther. 1995;57:62–66
- Lovastatin decreases coenzyme Q levels in humans. Proc Natl Acad Sci U S A. 1990;87:8931–8934
- Evidence of plasma CoQ10-lowering effect by HMG-CoA reductase inhibitors (a double-blind, placebo-controlled study). J Clin Pharmacol. 1993;33:226–229
- . Long-term efficacy and safety of coenzyme Q10 therapy for idiopathic dilated cardiomyopathy. Am J Cardiol. 1990;15:521–523
- Lipid-lowering drugs and mitochondrial function (effects of HMG-CoA reductase inhibitors on serum Q10 and blood lactate/pyruvate ratio). Br J Clin Pharmacol. 1996;42:333–337
- Effects of an inhibitor of 3-hydroxy-3-methylglutaryl Coenzyme A reductase on serum lipoprotein and ubiquinone-10 levels in patients with familial hypercholesterolemia. N Engl J Med. 1985;305:478–482
-
Statin-associated myopathy with normal creatine kinase levels.
Ann Intern Med. 2002;137:581–585
- Simvastatin-induced rhabdomyolysis followed by a MELAS syndrome. Am J Med. 1993;94:109–110
- . Lovastatin, isoprenes, and myopathy. Lancet. 1989;2:1097–1098
-
Co Q therapy in a patient with MELAS.
Acta Neurologica Scand. 1991;83:356–359
- Mitichondrial encephalomyopathy with coenzyme Q10 deficiency. Neurology. 1997;48:1238–1243
- Muscle coenzyme Q deficiency in familial mitochondrial encephalomyopathy. Proc Natl Acad Sci U S A. 1989;86:2379–2382
- Improvement of abnormal pyruvate metabolism and cardiac conduction defect with CoQ10 in Kearns-Sayre syndrome. Neurology. 1985;5:372–377
- Simvastatin-induced rhabdomyolysis followed by a MELAS syndrome. Am J Med. 1993;94:109–110
- . Fatal rhabdomyolysis caused by lipid-lowering therapy. South Med J. 2001;94:1023–1026
- . Interactions with hydroxymethylglutaryl-coenzyme A reductase inhibitors. Am J Health Syst Pharm. 1995;52:1639–1644
- . Myopathy and rhabdomyolysis associated with lovastatin-gemfibrozil combination therapy. JAMA. 1990;264:71–75
- . Rhabdomyolysis associated with concomitant use of atorvastatin and cyclosporine. Ann Pharmacother. 1999;33:1176–1179
- 3-Hydroxy-3-methylglutaryl coenzyme A reductase and isoprenylation inhibitors induce apoptosis of vascular smooth muscle cells in culture. Circ Res. 1998;83:490–500
- Inhibitors of HMG-CoA reductase sensitize human smooth muscle cells to Fas-ligand and cytokine-induced cell death. Atherosclerosis. 2000;152:217–227
- Tyrosine phosphorylation of the catalytic subunit p110 of phosphatidylinositol-3 kinase induced by HMG-CoA reductase inhibitor inhibits its kinase activity in L6 myoblasts. FEBS Letters. 2001;508:53–56
- Ras family genes (an interesting link between cell cycle and cancer). J Cell Physiol. 2002;192:125–130
- . Myopathy and rhabdomyolysis with lipid-lowering drugs. Toxicol Lett. 2002;128:159–168
- Dissociation of hypolipidemic and antiplatelet actions from adverse myotonic effects of clofibric acid related enantiomers. J Med Chem. 1987;30:1265–1267
- Experimental evaluation of the effects of pravastatin on electrophysiological parameters of rat skeletal muscle. Pharmacol Toxicol. 1992;71:325–329
- . Metabolism and drug interactions of 3-hydroxy-3-methylglutaryl coenzyme A-reductase inhibitors (statins). Eur J Clin Pharmacol. 2001;57:357–364
- Lipid-lowering long-term effects of six different statins in hypercholesterolemic renal transplant patients under cyclosporine immunosuppression. Transplant Proc. 2002;34:398–400
- Cholestasis and regulation of genes related to drug metabolism and biliary transport in rat liver following treatment with cylosporine A and sirolimus. Pharmacol Toxicol. 2001;89:133–139
- HMG-CoA reductase inhibitor-induced myopathy in the rat (cyclosporine A interaction and mechanism studies). J Pharmacol Exp Ther. 1991;257:1225–1235
- . Fibrates and statins in the treatment of hyperlipidaemia (an appraisal of their efficacy and safety). Eur Heart J. 1995;16:5–13
- . Statin-fibrate combination therapy. Ann Pharmacother. 2001;35:908–917
- Glucuronidation of statins in animals and humans. Drug Metab Dispos. 2002;30:505–512
- . Cholesterol-lowering agent myopathy (CLAM). Neurology. 1991;41:1159–1160
- . Myopathy and rhabdomyolysis associated with lovastatin-gemfibrozil combination therapy. JAMA. 1990;264:71–75
- ACC/AHA/NHLBI Clinical Advisory on the Use and Safety of Statins. Circulation. 2002;106:1024–1028
-
.
Statins (rhabdomyolysis and myopathy).
Can Adverse Drug React Newsletter. 2002;12:1–3
- . Statin myopathies (pathophysiologic and clinical perspectives). Clin Invest Med. 2001;24:258–272
- . Rhabdomyolysis and statin therapy (relevance to the elderly). Am J Geriatr Cardiol. 2002;11:48–55
- Lovastatin decreases coenzyme Q levels in rats. Proc Natl Acad Sci U S A. 1990;87:8928–8930
☆ Dr. Eisenberg is a Physician-Scientist of the Quebec Foundation for Health Research.
PII: S0002-8703(04)00059-6
doi: 10.1016/j.ahj.2003.12.037
© 2004 Elsevier Inc. All rights reserved.
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American Heart Journal
Volume 147, Issue 6
, Pages 956-965
, June 2004
