American Heart Journal
Volume 147, Issue 2 , Pages 228-237, February 2004

Conflict of interest

  • David R Holmes Jr, MD

      Affiliations

    • Mayo Clinic, Rochester, Minn, USA
    • Corresponding Author InformationReprint requests: David R. Holmes, Jr, MD, Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, 200 First Street NW, Rochester, MN 55905, USA
    • ,
  • Brian G Firth, MD, PhD

      Affiliations

    • Cordis Corporation, Warren, NJ, USA
    • ,
  • Astrid James, MBBS

      Affiliations

    • The Lancet, London, United Kingdom
    • ,
  • Ron Winslow, BA

      Affiliations

    • The Wall Street Journal, New York, NY, USA
    • ,
  • Patricia K Hodgson, BA

      Affiliations

    • Duke Clinical Research Institute, Durham, NC, USA
    • ,
  • Gail L Gamble, MD

      Affiliations

    • Mayo Clinic, Rochester, Minn, USA
    • ,
  • Richard L Popp, MD

      Affiliations

    • Stanford University, Stanford, Calif, USA
    • ,
  • Robert A Harrington, MD

      Affiliations

    • Duke Clinical Research Institute, Durham, NC, USA

Abstract 

The clinical research enterprise is increasingly scrutinized, in part because of the issue of conflict of interest. The issue is broad and its implications touch on a wide range of concerns, from the safety of patient care to the viability of a large industry. Numerous constituencies are affected by conflict of interest, and representatives of all of them convened in November 2002 for a one-and-a-half day discussion of the issues as well as possible solutions to both the perception and the actuality of such conflict. Participants included medical journal editors, news reporters, physician investigators, representatives of institutional conflict-of-interest oversight committees, representatives of the medical products industry, and Federal regulators. The resulting manuscript provides a review of the issues as well as desirable ways for each of the players to monitor themselves; each section thus contains provocative recommendations for eliminating conflict of interest to ensure that our vibrant health care system continues to foster exciting new advances to improve patient care.

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PII: S0002-8703(03)00833-0

doi:10.1016/j.ahj.2003.12.001

American Heart Journal
Volume 147, Issue 2 , Pages 228-237, February 2004

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