American Heart Journal
Volume 146, Issue 6 , Pages 929-931 , December 2003

Where the rubber meets the road in pharmacogenetics: assessment of gene-environment interactions

  • Elizabeth R. Hauser, PhD

      Affiliations

    • Center of Human Genetics, Duke University Medical Center, Durham, NC, USA
    • Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NCUSA
    • Corresponding Author InformationReprint requests: Elizabeth R. Hauser, PhD, PO Box 3445, Duke University Medical Center, Durham, NC 27710, USA.
    • ,
  • Andrew S. Allen, PhD

      Affiliations

    • Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA
    • Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NCUSA

  • Image Result

    Empirical power of gene × treatment interaction tests. The three curves denote the power of a study with the same number of subjects as the orginal Carlquist et al sample (n × 1), 2 times the Carlquis

    Empirical power of gene × treatment interaction tests. The three curves denote the power of a study with the same number of subjects as the orginal Carlquist et al sample (n × 1), 2 times the Carlquist et al sample size (n × 2), and 4 times the sample size (n × 4). Empirical power computed via 1000 simulated datasets. Interaction test is performed assuming a 0.05 α level.

PII: S0002-8703(03)00502-7

doi: 10.1016/S0002-8703(03)00502-7

American Heart Journal
Volume 146, Issue 6 , Pages 929-931 , December 2003

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