Clinical investigationsAnginal symptoms consistently predict total mortality among outpatients with coronary artery disease☆
Section snippets
Study design and population
These analyses used prospectively collected data from ACQUIP. The goal, design and components of the trial have been summarized previously.25 The protocol was approved by the institutional review board of each center, and all subjects gave informed written consent. Between January 1997 and March 2000, all outpatients assigned a primary provider and seen in the last year at the general internal medicine clinics at 7 Veterans Affairs Medical Centers (Birmingham, Little Rock, Richmond, San
Patient population
Selected baseline characteristics are shown overall and according to physical limitation due to angina (Table I). Average age at baseline was 67.6 years. As expected for a population of veterans with CAD, 98.3% were male. One third were nonwhite, and one quarter had diabetes. Approximately 1 in 5 participants had clinical CHF, nearly half reported prior coronary revascularization, and nearly half reported prior MI. Characteristics of persons excluded due to missing SAQ information were
Discussion
We observed a strong, graded, and independent relationship between anginal symptoms, as assessed by the SAQ, and total mortality among these outpatients with CAD. These results confirm the previously observed relationship between anginal symptoms and mortality seen at 1 year among a subset of these participants.12 More importantly, these findings extend the prior report by demonstrating that self-reported anginal symptoms—specifically, physical limitation due to angina and anginal
Acknowledgements
Support for Drs Bryson and Mozaffarian was provided by Veterans Affairs Health Services Research & Development fellowships at the Veterans Affairs Puget Sound Health Care System.
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Drs Bryson and Mozaffarian contributed equally to this work.