American Heart Journal
Volume 146, Issue 5 , Pages 775-786 , November 2003

Intracoronary brachytherapy for the prevention of restenosis after percutaneous coronary revascularization

  • Richard Sheppard, MD

      Affiliations

    • Division of Cardiology, Royal Victoria Hospital, Montreal, Quebec, Canada
    • ,
  • Mark J Eisenberg, MD, MPH

      Affiliations

    • Divisions of Cardiology and Clinical Epidemiology, Jewish General Hospital, Montreal, Quebec, Canada
    • Corresponding Author InformationReprint requests: Mark J Eisenberg, MD, MPH, Associate Professor of Medicine, Divisions of Cardiology and Clinical Epidemiology, Jewish General Hospital/McGill University, 3755 Cote St. Catherine Road/Suite A-118, Montreal, Quebec H3T 1E2, Canada.
    • ,
  • David Donath, MD

      Affiliations

    • Department of Radiation Oncology, Centre Hopital Université de Montréal, Hopital Notre Dame, Montreal, Quebec, Canada
    • ,
  • David Meerkin, MB, BS

      Affiliations

    • Cardiac Catheterization and Coronary Intervention Laboratories, Shaare Zedek Medical Center, Jerusalem, Israel

Received 20 September 2002 ,Accepted 21 March 2003.

References 

  1. Fischman D, Leon M, Baim D, et al.  A randomized comparison of coronary-stent placement and balloon angioplasty in the treatment of coronary artery disease. N Engl J Med. 1994;331:496–501
  2. Serruys PW, de Jaegere P, Kiemeneij F, et al.  A comparison of balloon-expandable-stent implantation with balloon angioplasty in patients with coronary artery disease. N Engl J Med. 1994;331:489–495
  3. Kimura T, Kaburagi S, Tamura T, et al.  Remodeling of human coronary arteries undergoing angioplasty or atherectomy. Circulation. 1997;96:475–483
  4. Kimura T, Nobuyoshi M. Remodeling and restenosis (intravascular ultrasound studies). Semin Interv Cardiol. 1997;2:159–166
  5. Schwartz R, Topol E, Serruys PW, et al.  Artery size, neointima and remodeling-time for some standards. J Am Coll Cardiol. 1998;32:2087–2094
  6. Mintz G, Popma J, Pichard A, et al.  Arterial remodeling after coronary angioplasty (a serial intravascular ultrasound study). Circulation. 1996;94:35–43
  7. Hojo Y, Ikeda U, Katsuki T, et al.  Interleukin 6 expression in coronary circulation after coronary angioplasty as a risk factor for restenosis. Heart. 2000;84:83–87
  8. Tardif JC, Cote G, Lesperance J, et al.  Probucol and multivitamins in the prevention of restenosis after coronary angioplasty (Multivitamins and Probucol Study Group). N Engl J Med. 1997;337:336–372
  9. Lee CW, Chae JK, Lim HY, et al.  Prospective randomized trial of corticosteroids for the prevention of restenosis after intracoronary stent implantation. Am Heart J. 1999;138:60–63
  10. Frishman WH, Chiu R, Landzberg BR, et al.  Medical therapies for the prevention of restenosis after percutaneous coronary interventions. Curr Prob Cardiol. 1998;23:534–635
  11. Kovalic JJ, Perez CA. Radiation therapy following keloidectomy (a 20-year experience). Int J Radiol Oncol Biol Phys. 1989;17:77–80
  12. Meerkin D, Tardif JC, Crocker IR, et al.  Effects of intracoronary beta-irradiation therapy after coronary angioplasty (an intravascular ultrasound study). Circulation. 1999;99:1660–1665
  13. MacLeod D, Strauss B, de Jong M, et al.  Proliferation and extracellular matrix synthesis of smooth muscle cells cultured from human coronary atherosclerotic and restenotic lesions. J Am Coll Cardiol. 1994;23:59–65
  14. Waksman R, Serruys PW. Handbook of Vascular Brachytherapy. 2nd ed. Martin Dunitz Ltd Publ: 2000
  15. Wiedermann JG, Marboe C, Amols H, et al.  Intracoronary irradiation markedly reduces neointimal proliferation after balloon angioplasty in swine (persistent benefit at 6-month follow-up). J Am Coll Cardiol. 1994;23:1491–1498
  16. Waksman R, Robinson K, Crocker I, et al.  Intracoronary low-dose β-irradiation inhibits neointima formation after coronary artery balloon injury in the swine restenosis model. Circulation. 1995;92:3025–3031
  17. Waksman R, Robinson K, Crocker I, et al.  Intracoronary radiation before stent implantation inhibits neointima formation in stented porcine coronary arteries. Circulation. 1995;92:1383–1386
  18. Waksman R, Robinson K, Crocker I, et al.  Endovascular low-dose irradiation inhibits neointima formation after coronary artery balloon injury in swine (a possible role for radiation therapy in restenosis prevention). Circulation. 1995;91:1533–1539
  19. Weinberger J, Amols H, Ennis R, et al.  Intracoronary irradiation (dose response for the prevention of restenosis in swine). Int J Rad Oncol Biol Phys. 1996;36:767–775
  20. Carter A, Laird J, Bailey L, et al.  Effects of endovascular radiation from a beta-particle-emitting stent in a porcine coronary restenosis model. Circulation. 1996;94:2364–2368
  21. Schulz C, Niederer C, Andres C, et al.  Endovascular irradiation from beta-particle-emitting gold stents results in increased neointima formation in a porcine restenosis model. Circulation. 2000;101:1970–1975
  22. Carter AJ, Scott D, Bailey L, et al.  Dose-response effects of 32P radioactive stents in an atherosclerotic porcine coronary model. Circulation. 1999;100:1548–1554
  23. Teirstein P, Massulo V, Jani S, et al.  Catheter-based radiotherapy to inhibit restenosis after coronary stenting. N Eng J Med. 1997;336:1697–1703
  24. Teirstein P, Massulo V, Jani S, et al.  Three year clinical and angiographic follow-up after intracoronary radiation (results of a randomized clinical trial). Circulation. 2000;101:360–365
  25. Waksman R, White LR, Chan RC, et al.  Intracorornary gamma radiation therapy after angioplasty inhibits recurrence in patients with in-stent restenosis (WRIST). Circulation. 2000;101:2165–2171
  26. Raizner A, Oesterle S, Waksman R, et al.  Inhibition of restenosis with beta-emitting radiotherapy (report of the proliferation reduction with vascular energy trial (PREVENT)). Circulation. 2000;102:951–958
  27. Leon MB, Teirstein PS, Lansky AJ, et al.  Localized intracoronary gamma radiation therapy to inhibit the recurrence of restenosis after stenting. N Engl J Med. 2001;344:250–256
  28. Popma JJ, Sunthalaringam M, Lansky AJ, et al.  Randomized trial of 90Sr/90Y beta-radiation versus placebo control for treatment of in-stent restenosis. Circulation. 2002;106:1090–1096
  29. Waksman R, Raizner AE, Yeung AC, et al.  Use of localized intracoronary beta radiation in treatment of in-stent restenosis (the INHIBIT randomized controlled trial). Lancet. 2002;359:551–557
  30. Waksman R, Ajani AE, White RL, et al.  Intravascular gamma radiation for in-stent restenosis in saphenous vein bypass grafts. N Engl J Med. 2002;346:1194–1199
  31. Ahmed JM, Mintz GS, Waksman R, et al.  Serial intravascular ultrasound assessment of the efficacy of intracoronary gamma-radiation therapy for preventing recurrence in very long, diffuse, in-stent restenosis lesions. Circulation. 2001;104:856–859
  32. Waksman R, Bhargava B, White L, et al.  Intracoronary beta-radiation therapy inhibits recurrences of in-stent restenosis. Circulation. 2000;101:1895–1898
  33. King SB, Williams DO, Chougoule P, et al.  Endovascular beta-radiation to reduce restenosis after coronary balloon angioplasty (results of the beta restenosis trial (BERT)). Circulation. 1998;97:2025–2030
  34. Verin V, Popowski Y, de Bruyne B, et al.  Endoluminal beta-radiation therapy for the prevention of coronary restenosis after balloon angioplasty. N Engl J Med. 2001;344:243–249
  35. Hoher M, Wohrle J, Wohlfrom M, et al.  Intracoronary β-irradiation with a liquid filled 188Re-filled balloon (six-month results from a clinical safety and feasibility study). Circulation. 2000;101:2355–2360
  36. Condado J, Waksman R, Gurdiel O, et al.  Long term angiographic and clinical outcome after percutaneous transluminal coronary angioplasty and intracoronary radiation therapy in humans. Circulation. 1997;96:727–732
  37. Verin V, Urban P, Popowski Y, et al.  Feasability of beta-irradiation to reduce restenosis after balloon angioplasty (a clinical pilot study). Circulation. 1997;95:1138–1144
  38. Albiero R, Adamian M, Kobayahi N, et al.  Short and intermediate results pf 32P beta-emitting stent implantation in patients with coronary artery disease (the Milan dose response study). Circulation. 2000;101:18–26
  39. Wardeh AJ, Kay I, Sabate M, et al.  Beta-particle emitting radioactive stent implantation (a safety and feasability study (isostents for restenosis intervention study: IRIS)). Circulation. 1999;100:1684–1689
  40. Sheppard R, Eisenberg MJ. Intracoronary radiotherapy for restenosis. N Engl J Med. 2001;344:295–297
  41. Costa M, Sabate M, Van der Giessen W, et al.  Late coronary occlusion after intracoronary brachytherapy. Circulation. 1999;100:789–792
  42. Waksman R, Bhargava B, Mintz G, et al.  Late total occlusion after intracoronary brachytherapy for patients with in-stent restenosis. J Am Coll Cardiol. 2000;36:65–68
  43. Waksman R, Ajani AE, Pinnow E, et al.  Twelve versus six months of clopidogrel to reduce major cardiac events in patients undergoing gamma-radiation therapy for in-stent restenosis (Washington radiation for in-stent restenosis trial (WRIST) 12 versus WRIST PLUS). Circulation. 2002;106:776–778
  44. Waksman R, Ajani AE, White RL, et al.  Prolonged antiplatelet therapy to prevent late thrombosis after intracoronary gamma-radiation in patients with in-stent restenosis (Washington radiation for in-stent restenosis trial plus 6 months of clopidogrel (WRIST PLUS)). Circulation. 2001;103:2332–2335
  45. Grise MA, Massullo V, Jani S, et al.  Five-year clinical follow-up after intracoronary radiation (results of a randomized clinical trial). Circulation. 2002;105:2737–2740
  46. Ajani AE, Waksman R, Sharma AK, et al.  Three-year follow-up after intracoronary gamma radiation therapy for in-stent restenosis (original WRIST. Washington radiation for in-stent restenosis trial). Cardiovasc Radiat Med. 2001;2:200–204
  47. Albiero R, Nishida T, Adamian M, et al.  Edge restenosis after implantation of high activity (32)P radioactive beta-emitting stents. Circulation. 2000;101:2454–2457
  48. Serruys P, Kay P. I like the candy, I hate the wrapper (the 32P radioactive stent). Circulation. 2000;101:3–7
  49. Sabata M, Costa MA, Kozuma K, et al.  Geographic miss (a cause of treatment failure in radio-oncology applied to intracoronary radiation therapy). Circulation. 2000;101:2467–2471
  50. Tassile D, Roth AD, Kurt AM. Colon cancer and peritoneal mesothelioma occurring 29 years after abdominal radiotherapy for testicular seminoma-a case report and review of the literature. Oncology. 1998;55:289–292
  51. Stewart JR, Fajard LF, Gillette SM, et al.  Radiation injury to the heart. Int J Radiat Oncol Biol Phys. 1995;31:1205–1211
  52. Jani S, Steuterman S, Huppe G, et al.  Radiation safety of personnel during catheter-based Ir-192 coronary brachytherapy. J Inv Cardiol. 2000;12:286–290
  53. Balter S, Oetgen M, Hill A, et al.  Personnel exposure during gamma endovascular brachytherapy. Health Phys. 2000;79:136–146
  54. Shirish K. Jani. Gamma vs beta irradiation (which is superior?). Cardiovasc Rad Med. 1999;1:102–106
  55. Thorin E, Meerkin D, Bertrand O, et al.  Influence of postangioplasty beta-irradiation on endothelial function in porcine coronary arteries. Circulation. 2000;101:1430–1435
  56. Meerkin D, Tardif JC, Bertrand OF, et al.  The effects of intracoronary brachytherapy on the natural history of postangioplasty dissections. J Am Coll Cardiol. 2000;36:59–64

PII: S0002-8703(03)00389-2

doi: 10.1016/S0002-8703(03)00389-2

American Heart Journal
Volume 146, Issue 5 , Pages 775-786 , November 2003

Article Tools

* Image Usage & Resolution