American Heart Journal
Volume 146, Issue 2 , Pages 234-241 , August 2003

Danish multicenter randomized study on fibrinolytic therapy versus acute coronary angioplasty in acute myocardial infarction: rationale and design of the danish trial in acute myocardial infarction-2 (DANAMI-2)

  • Henning Rud Andersen, MD

      Affiliations

    • Department of Cardiology, Skejby Hospital, Aarhus University Hospital, Aarhus, Denmark
    • Corresponding Author InformationReprint requests: Henning Rud Andersen, MD, Department of Cardiology B, Skejby Sygehus, Aarhus University Hospital, Brendstrupgaardsvej, DK-8200, Aarhus N, Denmark.
    • ,
  • Torsten Toftegaard Nielsen, MD

      Affiliations

    • Department of Cardiology, Skejby Hospital, Aarhus University Hospital, Aarhus, Denmark
    • ,
  • Thomas Vesterlund, MD

      Affiliations

    • Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark
    • ,
  • Peer Grande, MD

      Affiliations

    • The Heart Center, Department of Cardiology, Rigshospitalet University Hospital, Copenhagen, Denmark
    • ,
  • Ulrik Abildgaard, MD

      Affiliations

    • Department of Cardiology, Gentofte Hospital, Hellerup, Denmark
    • ,
  • Per Thayssen, MD

      Affiliations

    • Department of Cardiology, Odense University Hospital, Odense, Denmark
    • ,
  • Flemming Pedersen, MD

      Affiliations

    • Department of Medicine, Hilleroed Hospital, Hilleroed, Denmark
    • ,
  • Leif Spange Mortensen, MSc

      Affiliations

    • UNI-C, Danish IT Centre for Education and Research, Aarhus, Hilleroed, Denmark
    • ,
  • DANAMI-2 Investigators

Received 29 April 2003 ,Accepted 12 May 2003.

References 

  1. Grines CL, Browne KF, Marco J, et al.  A comparison of immediate angioplasty with thrombolytic therapy for acute myocardial infarction. The Primary Angioplasty in Myocardial Infarction Study Group. N Engl J Med. 1993;328:673–679
  2. Zijlstra F, de Boer MJ, Hoorntje JC, et al.  A comparison of immediate coronary angioplasty with intravenous streptokinase in acute myocardial infarction. N Engl J Med. 1993;328:680–684
  3. Gibbons RJ, Holmes DR, Reeder GS, et al.  Immediate angioplasty compared with the administration of a thrombolytic agent followed by conservative treatment for myocardial infarction. N Engl J Med. 1993;328:685–691
  4. Keeley EC, Boura J, Grines CL. Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction (a quantitative review of 23 randomised trials). Lancet. 2003;361:13–20
  5. Grines CL, Westerhausen DR, Grines LL, et al.  A randomized trial of transfer for primary angioplasty versus on-site thrombolysis in patients with high-risk myocardial infarction (the Air Primary Angioplasty in Myocardial Infarction study). J Am Coll Cardiol. 2002;39:1713–1719
  6. Widimsky P, Budesinsky T, Vorac D, et al.  Long distance transport for primary angioplasty vs immediate thrombolysis in acute myocardial infarction. Eur Heart J. 2003;24:94–104
  7. Andersen HR, Nielsen TT, Rasmussen K, et al. A comparison of coronary angioplasty with fibrinolytic therapy in acute myocardial infarction. N Engl J Med in press

☆ Supported by grants from the Danish Heart Foundation, The Danish Medical Research Council, Astra-Zeneca, Bristol-Myers Squibb, Cordis, a Johnson & Johnson Company, Pfizer, Pharmacia-Upjohn, Boehringer Ingelheim and Logic I/S Guerbet SA.

PII: S0002-8703(03)00316-8

doi: 10.1016/S0002-8703(03)00316-8

American Heart Journal
Volume 146, Issue 2 , Pages 234-241 , August 2003

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