American Heart Journal
Volume 143, Issue 5 , Pages 797-801 , May 2002

Association of a novel single nucleotide polymorphism of the prostacyclin synthase gene with myocardial infarction

  • Tomohiro Nakayama, MD

      Affiliations

    • Division of Receptor Biology, Advanced Medical Research Center Tokyo, Japan
    • ,
  • Masayoshi Soma, MD

      Affiliations

    • 2nd Department of Internal Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan
    • ,
  • Satoshi Saito, MD

      Affiliations

    • 2nd Department of Internal Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan
    • ,
  • Junko Honye, MD

      Affiliations

    • 2nd Department of Internal Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan
    • ,
  • Junji Yajima, MD

      Affiliations

    • 2nd Department of Internal Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan
    • ,
  • Dolkun Rahmutula, MD

      Affiliations

    • 2nd Department of Internal Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan
    • ,
  • Yukie Kaneko, MD

      Affiliations

    • 2nd Department of Internal Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan
    • ,
  • Mikano Sato, MD

      Affiliations

    • 2nd Department of Internal Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan
    • ,
  • Jiro Uwabo, MD

      Affiliations

    • 2nd Department of Internal Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan
    • ,
  • Noriko Aoi, MD

      Affiliations

    • 2nd Department of Internal Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan
    • ,
  • Kotoko Kosuge, MD

      Affiliations

    • 2nd Department of Internal Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan
    • ,
  • Masako Kunimoto, MD

      Affiliations

    • 2nd Department of Internal Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan
    • ,
  • Katsuo Kanmatsuse, MD

      Affiliations

    • 2nd Department of Internal Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan
    • ,
  • Shinichiro Kokubun, MD

      Affiliations

    • Division of Receptor Biology, Advanced Medical Research Center Tokyo, Japan

Received 5 June 2001 ,Accepted 3 December 2001.

References 

  1. Marenberg ME, Risch N, Berkman LF, et al.  Genetic susceptibility to death from coronary heart disease in a study of twins. N Engl J Med. 1994;330:1041–1046
  2. Nora JJ, Lortscher RH, Spangler RD, et al.  Genetic-epidemiologic study of early-onset ischemic heart disease. Circulation. 1980;61:503–508
  3. Cambien F, Poirier O, Lecerf L, et al.  Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction. Nature. 1992;359:641–644
  4. van Bockxmeer FM, Mamotte CDS. Apolipoprotein 4 homozygosity in young men with coronary heart disease. Lancet. 1992;340:879–880
  5. Weiss EJ, Bray PF, Tayback M, et al.  A polymorphism of a platelet glycoprotein receptor as an inherited risk factor for coronary thrombosis. N Engl J Med. 1996;334:1090–1094
  6. Wu KK. Platelet activation mechanisms and markers in arterial thrombosis. J Intern Med. 1996;239:17–34
  7. Patrono C. Prevention of myocardial infarction and stroke by aspirin: different mechanisms? Different dosage?. Thromb Res. 1998;92(1 Suppl):S7–S12
  8. Trip MD, Cats VM, van Capelle FJ, et al.  Platelet hyperreactivity and prognosis in survivors of myocardial infarction. N Engl J Med. 1990;322:1549–1554
  9. Svensson J, Hamberg M, Samuelsson B. On the formation and effects of thromboxane A2 in human platelets. Acta Physiol Scand. 1976;98:285–294
  10. Moncada S, Gryglewski RJ, Bunting S, et al.  An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature. 1976;263:663–665
  11. Pober JS, Cotran RS. Cytokines and endothelial cell biology. Physiol Rev. 1990;70:427–455
  12. Bunting S, Moncada S, Vane JR. The prostacyclin-thromboxane A2 balance: pathophysiological and therapeutic implications. Br Med Bull. 1983;39:271–276
  13. Oates JA, FitzGerald GA, Branch RA. Clinical implications of prostaglandin and thromboxane A2 formation. N Engl J Med. 1988;319:689–717
  14. Yokoyama C, Yabuki T, Inoue H, et al.  Human gene encoding prostacyclin synthase (PTGIS): genomic organization, chromosomal localization, and promoter activity. Genomics. 1996;36:296–304
  15. Nakayama T, Soma M, Izumi Y, et al.  Organization of the human prostacyclin synthase gene. Biochem Biophys Res Commun. 1996;221:803–806
  16. Nakayama T, Soma M, Rehemudula D, et al.  Association of 5′ upstream promoter region of prostacyclin synthase gene variant with cerebral infarction. Am J Hypertens. 2000;13:1263–1267
  17. Williams RR, Hunt SC, Hopkins PN, et al.  Familial dyslipidemic hypertension: evidence from 58 Utah families for syndrome present in approximately 12% of patients with essential hypertension. JAMA. 1988;259:3579–3586
  18. Nakayama T, Soma M, Rahmutula D, et al.  Isolation of the 5′-flanking region of genes by thermal asymmetric interlaced polymerase chain reaction. Med Sci Monit. 2001;7:345–349
  19. Creed L, Wu K. Platelet function and antiaggregant therapy in ischemic stroke. Semin Neurol. 1986;6:293–298
  20. Vane J. Prostacyclin in the cardiovascular system in health and disease. In:  Schror K editors. Prostaglandins and other eicosanoids cardiovascular system. Basel: Karger; 1985;p. 7–28
  21. Nakayama T, Soma M, Rahmutula D, et al.  Nonsense mutation of prostacyclin synthase gene in a family. Lancet. 1997;349:1887–1888
  22. Nakayama T, Soma M, Takahashi Y, et al.  Polymorphism of the promoter region of prostacyclin synthase gene is not associated with essential hypertension. Am J Hypertens. 2001;14:409–411

☆ Supported by a grant from the Ministry of Education, Science and Culture of Japan (High-Tech Research Center, Nihon University), a research grant from an alumni association of Nihon University School of Medicine, Tanabe Biomedical Conference, and the Toray-Yamanouchi Pharmacology Company, Japan.

☆☆ Reprint requests: Tomohiro Nakayama, MD, Division of Receptor Biology, Advanced Medical Research Center, Ooyaguchi-kamimachi 30-1, Itabashi-ku, Tokyo 173-8610, Japan.

★ E-mail: tnakayam@med.nihon-u.ac.jp

PII: S0002-8703(02)82214-1

doi: 10.1067/mhj.2002.122171

American Heart Journal
Volume 143, Issue 5 , Pages 797-801 , May 2002

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