American Heart Journal
Volume 143, Issue 5 , Pages 797-801, May 2002

Association of a novel single nucleotide polymorphism of the prostacyclin synthase gene with myocardial infarction☆☆☆★

  • Tomohiro Nakayama, MD

      Affiliations

    • Division of Receptor Biology, Advanced Medical Research Center Tokyo, Japan
    • ,
  • Masayoshi Soma, MD

      Affiliations

    • 2nd Department of Internal Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan
    • ,
  • Satoshi Saito, MD

      Affiliations

    • 2nd Department of Internal Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan
    • ,
  • Junko Honye, MD

      Affiliations

    • 2nd Department of Internal Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan
    • ,
  • Junji Yajima, MD

      Affiliations

    • 2nd Department of Internal Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan
    • ,
  • Dolkun Rahmutula, MD

      Affiliations

    • 2nd Department of Internal Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan
    • ,
  • Yukie Kaneko, MD

      Affiliations

    • 2nd Department of Internal Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan
    • ,
  • Mikano Sato, MD

      Affiliations

    • 2nd Department of Internal Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan
    • ,
  • Jiro Uwabo, MD

      Affiliations

    • 2nd Department of Internal Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan
    • ,
  • Noriko Aoi, MD

      Affiliations

    • 2nd Department of Internal Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan
    • ,
  • Kotoko Kosuge, MD

      Affiliations

    • 2nd Department of Internal Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan
    • ,
  • Masako Kunimoto, MD

      Affiliations

    • 2nd Department of Internal Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan
    • ,
  • Katsuo Kanmatsuse, MD

      Affiliations

    • 2nd Department of Internal Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan
    • ,
  • Shinichiro Kokubun, MD

      Affiliations

    • Division of Receptor Biology, Advanced Medical Research Center Tokyo, Japan

Received 5 June 2001; accepted 3 December 2001.

Abstract 

Background Myocardial infarction (MI) is a complex multifactorial and polygenic disorder that is thought to result from an interaction between an individual's genetic makeup and various environmental factors. The purpose of this study was to investigate the association between a novel single nucleotide polymorphism in the prostacyclin synthase gene and MI. Methods and Results By the use of polymerase chain reaction-single-strand conformation polymorphism analysis, we identified a single nucleotide polymorphism, C1117A, in exon 8. This nucleotide change did not cause an amino acid change in codon 373. We performed an association study of the polymorphism in 138 patients and 130 healthy control subjects. Multiple logistic linear regression analysis showed the genotype distributions were significantly different between the control group and the MI group (odds ratio, 2.12; 95% CI, 1.47-3.05, P = .04). The C/C genotype was found more frequently in the MI group than in the control group. Conclusions We conclude that the C1117A polymorphism in exon 8 is associated with risk for MI and may be a genetic marker of MI in Japanese persons. (Am Heart J 2002;143:797-801.)

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☆ Supported by a grant from the Ministry of Education, Science and Culture of Japan (High-Tech Research Center, Nihon University), a research grant from an alumni association of Nihon University School of Medicine, Tanabe Biomedical Conference, and the Toray-Yamanouchi Pharmacology Company, Japan.

☆☆ Reprint requests: Tomohiro Nakayama, MD, Division of Receptor Biology, Advanced Medical Research Center, Ooyaguchi-kamimachi 30-1, Itabashi-ku, Tokyo 173-8610, Japan.

★ E-mail: tnakayam@med.nihon-u.ac.jp

PII: S0002-8703(02)82214-1

doi:10.1067/mhj.2002.122171

American Heart Journal
Volume 143, Issue 5 , Pages 797-801, May 2002

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