American Heart Journal
Volume 141, Issue 6 , Pages 881-883 , June 2001

PRINCE’s prospects: Statins, inflammation, and coronary risk

Received 5 February 2001 ,Accepted 20 February 2001.

References 

  1. Vaughn CJ, Gotto AM, Basson CT. The evolving role of statins in the management of atherosclerosis. J Am Coll Cardiol. 2000;35:1–10
  2. Cholesterol and Recurrent Events Trial Investigators . The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. N Engl J Med. 1996;335:1001–1009
  3. Treasure CB, Klein L, Weintraub WS, et al.  Beneficial effects of cholesterol-lowering therapy on the coronary endothelium in patients with coronary artery disease. N Engl J Med. 1995;332:481–487
  4. Lacoste L, Lam JYT, Hung J, et al.  Hyperlipidemia and coronary disease: correction of the increased thrombogenic potential with cholesterol reduction. Circulation. 1995;92:3172–3177
  5. Ridker PM, Rifai N, Pfeffer MA, et al.  Long-term effects of pravastatin on plasma concentration of C-reactive protein. Circulation. 1999;100:230–235
  6. Ridker PM, Cushman M, Stampfer MJ, et al.  Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med. 1997;336:973–979
  7. Liuzzo G, Biasucci LM, Gallimore JR, et al.  The prognostic value of C-reactive protein and serum amyloid A protein in severe unstable angina. N Engl J Med. 1994;331:417–424
  8. Biasucci LM, Liuzzo G, Grillo RL, et al.  Elevated levels of C-reactive protein at discharge in patients with unstable angina predicts recurrent instability. Circulation. 1999;99:855–860
  9. Azar RR, Rinfret S, Theroux P, et al.  A randomized placebocontrolled trial to assess the efficacy of anti-inflammatory therapy with methylprednisolone in unstable angina. Eur Heart J. 2000;21:2026–2032
  10. Maseri A. Inflammation, atherosclerosis, and ischemic events—exploring the hidden side of the moon. N Engl J Med. 1997;336:1014–1016
  11. Mehta J, Dinerman J, Mehta P, et al.  Neutrophil function in ischemic heart disease. Circulation. 1989;79:549–556
  12. Mazzone A, DeServi S, Ricevuti G, et al.  Increased expression of neutrophil and moncyte adhesion molecules in unstable coronary artery disease. Circulation. 1993;88:358–363
  13. Kai H, Ikeda H, Yasukawa H, et al.  Peripheral blood levels of matrix metalloproteases-2 and -9 are elevated in patients with acute coronary syndromes. J Am Coll Cardiol. 1998;32:368–372
  14. Ridker PM, Hennekens CH, Buring JE, et al.  C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med. 2000;342:836–843
  15. Ross R. Atherosclerosis: an inflammatory disease. N Engl J Med. 1999;340:115–126
  16. Van der Wal AC, Becker AE, van der Loos CM, et al.  Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology. Circulation. 1994;89:36–44
  17. Rosenson RS, Tangney CC. Antiatherosclerotic properties of statins. JAMA. 1998;279:1643–1650
  18. Davignon J, Laaksonen R. Low-density lipoprotein-independent effects of statins. Curr Opin Lipidol. 1999;10:543–559
  19. Ridker PM, Rifai N, Miles JS, et al.  Lovastatin 20-40 mg/day lowers high-sensitivity C-reactive protein levels in AFCAPS/TexCAPS. [abstract] Circulation. 2000;102(2 Suppl):II833
  20. Jialal I, Stein D, Balis D, et al.  Effect of HMG-CoA reductase inhibitors on C-reactive protein levels. [abstract] Circulation. 2000;102(2 Suppl):II833
  21. Weber C, Erl W, Weber KSC, et al.  HMG-CoA reductase inhibitors decrease CD11b expression and CD11b-dependent adhesion of monocytes to endothelium and reduce increased adhesiveness of monocytes isolated from patients with hypercholesterolemia. J Am Coll Cardiol. 1997;30:1212–1217

☆ Reprint requests: Rabih R. Azar, MD, MSc, FACC, Division of Cardiology, Hotel-Dieu de France Hospital, PO Box 16-6830, Achrafieh, Beirut, Lebanon. E-mail: razarmd@hotmail.com

☆☆ Am Heart J 2001;141:881-3.

PII: S0002-8703(01)91750-8

doi: 10.1067/mhj.2001.115298

American Heart Journal
Volume 141, Issue 6 , Pages 881-883 , June 2001

Article Tools