Inhibition by combined therapy with ticlopidine and aspirin of enhanced platelet aggregation during physical exercise in patients with coronary artery disease

Effects of exercise test on ADP- and collagen-induced platelet aggregation in patients with stable CAD. Blood was obtained before (PRE) and immediately after (POST) ergometer exercise test in patient control (no medication) group, ASA-alone group and ASA + TIC group. Box and whisker plots show mean value (open circles), median (horizontal lines), 25th and 75th percentiles (boxes), and 90th percentiles (error bars). Asterisk, P < .05; two asterisks, P < .001.

Typical curve of SIPA before (PRE) and after (POST) exercise test in a control patient with stable CAD. PRP was placed in a cone-plate viscometer and exposed to shear force, as described in Methods. The shear force applied to platelets is indicated by a broken line.

Effects of exercise test on SIPA in patients with stable CAD. Blood samples were taken before (PRE) and immediately after (POST) exercise from the patient control group, ASA-alone group and ASA + TIC group. Box and whisker plots are equivalent to those shown in Figure 1. Asterisk, P < .05; two asterisks, P < .001.

Effects of exercise test on VWF/RCO activity (upper panel) and vWF antigen (lower panel) in patients with CAD. Blood samples were taken before (PRE) and immediately after (POST) exercise in the patient control group, ASA-alone group, and ASA + TIC group. Box and whisker plots are equivalent to those shown in Figure 1. Asterisk, P < .05.

Correlation between the extent of SIPA and plasma vWF/RCO activity (upper panel) and vWF antigen (Ag) level (lower panel) before (closed circles) and after exercise (open circles) in the patient control group with CAD.

Effects of exercise test on levels of TAT (upper panel) and PIC (lower panel) in patients with stable CAD. Blood samples were taken before (PRE) and immediately after (POST) exercise in the patient control group, ASA-alone group, and ASA + TIC group. Asterisk, P < .05.