Elsevier

American Heart Journal

Volume 76, Issue 6, December 1968, Pages 799-811
American Heart Journal

Experimental and laboratory report
Hemodynamic effects of graded hypovolemia and vasodepressor syncope induced by lower body negative pressure,☆☆

https://doi.org/10.1016/0002-8703(68)90266-4Get rights and content

Abstract

To study the effects of graded hypovolemia and vasodepressor syncope, 7 normal subjects were instrumented with arterial and venous catheters, ECG electrodes, chest and forearm girth gauges (for respiratory rate and plethysmography), and exposed to graded degrees of lower body negative pressure, proceeding to syncope. Hemodynamic responses were generally similar to hypovolemia induced by other means: HR and SVR rose; mean blood pressure remained unchanged; pulse pressure, CO, SV, CBV, SW, forearm blood flow, and CVP fell; when hypovolemia became severe, CVP rose. At syncope, CVP rose further, while HR, arterial pressures, and SVR fell abruptly and CO continued falling; there was no significant change in forearm blood flow. All factors returned to or above control values in the recovery period. LBNP proved to be a reproducible, effective and practical means to produce hypovolemia and induce vasodepressor syncope.

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    The research reported in this paper was sponsored by the Aerospace Medical Research Laboratories, Aerospace Medical Division, Air Force Systems Command, Wright-Patterson Air Force Base, Ohio under Contract No. AF33 (616)-8378 with Indiana University Medical Center. This paper has been identified by Aerospace Medical Research Laboratories as AMRL-TR-67-79. Further reproduction is authorized to satisfy the needs of the United States Government.

    ☆☆

    The voluntary informed consent of the subjects used in this research was obtained as required by Air Force Regulation 169-8.

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