Experimental and laboratory reportHemodynamic effects of graded hypovolemia and vasodepressor syncope induced by lower body negative pressure☆,☆☆
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2013, Journal of Surgical ResearchCitation Excerpt :In the present study, elevated body temperature and decreased CBV were induced successively in healthy volunteers by whole-body heating combined with lower body negative pressure (LBNP) to investigate their distinct impact on the hemostatic system. Applied as separate interventions, both heat stress and LBNP have been shown to lower CBV [9,10] and lead to an activation of coagulation [11,12]. Furthermore, sympathetic activity increases during heat stress [13] and LBNP [14], and catecholamines are expected to modulate the coagulation system [15].
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The research reported in this paper was sponsored by the Aerospace Medical Research Laboratories, Aerospace Medical Division, Air Force Systems Command, Wright-Patterson Air Force Base, Ohio under Contract No. AF33 (616)-8378 with Indiana University Medical Center. This paper has been identified by Aerospace Medical Research Laboratories as AMRL-TR-67-79. Further reproduction is authorized to satisfy the needs of the United States Government.
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The voluntary informed consent of the subjects used in this research was obtained as required by Air Force Regulation 169-8.